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Roles of Cyclophilins in Cancers and Other Organ Systems

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Abstract

Cyclophilins are originally identified as cellular binding proteins for the immunosuppressive drug cyclosporin A. Many cyclophilins, including CypA, CypB, CypC, CypD, and Cyp40, have been discovered and shown to be ubiquitously distributed in many types of cells and organ systems. Recent investigations have uncovered many important properties and functions for cyclophilins including peptidyle-prolyl-isomerase activity and protein folding/repair; maintaining mitochondrial functions and involvement in apoptosis; roles in regulation of T-cell function and inflammation; interaction with CD147; and pathogenesis of vascular disease, human immunodeficiency virus infection, and rheumatoid arthritis. Furthermore, the expression and functions of cyclophilins may be correlated with tumor biology of several types of cancers including pancreatic carcinoma. Molecular mechanisms of cyclophilin-mediated biologic events and future directions of research are discussed in this review. Understanding the roles of cyclophilins in cancers and other organ systems will be crucial in determining clinical applications for the treatment or diagnosis of human diseases.

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References

  1. RE Handschumacher MW Harding J Rice et al. (1984) ArticleTitleCyclophilin: a specific cytosolic binding protein for cyclosporin A Science 226 544–547 Occurrence Handle1:CAS:528:DyaL2MXktFOmtg%3D%3D Occurrence Handle6238408

    CAS  PubMed  Google Scholar 

  2. V Mikol J Kallen G Pflugl et al. (1993) ArticleTitleX-ray structure of monmeric cyclophilin A-cycloporin A crystal complex at 2.1 A resolution J. Mol. Biol. 234 1119–1130 Occurrence Handle10.1006/jmbi.1993.1664 Occurrence Handle1:CAS:528:DyaK2cXmvVyktw%3D%3D Occurrence Handle8263916

    Article  CAS  PubMed  Google Scholar 

  3. A Galat SM Metcalfe (1995) ArticleTitlePeptidylproline cis/trans isomerases Prog. Biophys. Mol. Biol. 63 67–118 Occurrence Handle10.1016/0079-6107(94)00009-X Occurrence Handle1:CAS:528:DyaK2MXlsFWksL8%3D Occurrence Handle7538221

    Article  CAS  PubMed  Google Scholar 

  4. DJ Bergsma C Eder M Gross et al. (1991) ArticleTitleThe cyclophilin multigene family of peptidyl-prolyl isomerases: characterization of three separate human isoforms J. Biol. Chem. 266 23204–23214 Occurrence Handle1:CAS:528:DyaK3sXjtlOjug%3D%3D Occurrence Handle1744118

    CAS  PubMed  Google Scholar 

  5. F Allain C Boutillon C Mariller et al. (1995) ArticleTitleSelective assay for CypA and CypB in human blood using highly specific anti-peptide antibodies J. Immunol. Methods 178 113–120 Occurrence Handle10.1016/0022-1759(94)00249-V Occurrence Handle1:CAS:528:DyaK2MXjt1Wjsb0%3D Occurrence Handle7829860

    Article  CAS  PubMed  Google Scholar 

  6. LJ Kieffer T Thalhammer RE Handschumacher (1992) ArticleTitleIsolation and characterization of a 40-kDa cyclophilin-related protein J. Biol. Chem. 267 5503–5507 Occurrence Handle1:CAS:528:DyaK38XhvV2rsLc%3D Occurrence Handle1544925

    CAS  PubMed  Google Scholar 

  7. K Hoffman RE Handschumacher (1995) ArticleTitleCyclophilin-40: evidence for a dimeric complex with Hsp90 Biochem. J. 307 5–8 Occurrence Handle7717993

    PubMed  Google Scholar 

  8. K Dolinski C Scholz RS Muir et al. (1997) ArticleTitleFunctions of FKBP12 and mitochondrial cyclophilin active site residues in vitro and in vivo in Saccharomyces cerevisiae Mol. Biol. Cell 8 2267–2280 Occurrence Handle1:CAS:528:DyaK2sXntFyrtrs%3D Occurrence Handle9362068

    CAS  PubMed  Google Scholar 

  9. G Fischer H Bang C Mech (1984) ArticleTitleDetermination of enzymatic catalysis for the cis-trans-isomerization of peptide binding in proline-containing peptides Biomed. Biochim. Acta 43 1101–1111 Occurrence Handle1:CAS:528:DyaL2MXhtVymtLw%3D Occurrence Handle6395866

    CAS  PubMed  Google Scholar 

  10. B Steinmann P Bruckner A Superti-Furga (1991) ArticleTitleCyclosporin A slows collagen triple-helix formation in vivo: indirect evidence for a physiologic role of peptidyl-prolyl cis-trans-isomerase J. Biol. Chem. 266 1299–1303 Occurrence Handle1:CAS:528:DyaK3MXit1Sqtrg%3D Occurrence Handle1985948

    CAS  PubMed  Google Scholar 

  11. M Kruse M Brunke A Escher et al. (1995) ArticleTitleEnzyme assembly after de novo synthesis in rabbit reticulocyte lysate involves molecular chaperones and immunophilins J. Biol. Chem. 270 2588–2594 Occurrence Handle10.1074/jbc.270.6.2588 Occurrence Handle1:CAS:528:DyaK2MXjs1Kmt7o%3D Occurrence Handle7852322

    Article  CAS  PubMed  Google Scholar 

  12. EA Craig BD Gambill RJ Nelson (1993) ArticleTitleHeat shock proteins: molecular chaperones of protein biogenesis Microbiol. Rev. 57 402–414 Occurrence Handle1:CAS:528:DyaK3sXlslOitbo%3D Occurrence Handle8336673

    CAS  PubMed  Google Scholar 

  13. DA Parsell S Lindquist (1993) ArticleTitleThe function of heat-shock proteins in stress tolerance: degradation and reactivation of damaged proteins Annu. Rev. Genet. 27 437–496 Occurrence Handle10.1146/annurev.ge.27.120193.002253 Occurrence Handle1:CAS:528:DyaK2cXhvVGnt7o%3D Occurrence Handle8122909

    Article  CAS  PubMed  Google Scholar 

  14. BC Freeman DO Toft RI Morimoto (1996) ArticleTitleMolecular chaperone machines: chaperone activities of the cyclophilin Cyp-40 and the steroid aporeceptor-associated protein p23 Science 274 1718–1720 Occurrence Handle10.1126/science.274.5293.1718 Occurrence Handle1:CAS:528:DyaK28Xntlyrt7g%3D Occurrence Handle8939864

    Article  CAS  PubMed  Google Scholar 

  15. J Zou Y Guo T Guettouche et al. (1998) ArticleTitleRepression of heat shock transcription factor HSF1 activation by HSP90 (HSP90 complex) that forms a stress-sensitive complex with HSF1 Cell 94 471–480 Occurrence Handle10.1016/S0092-8674(00)81588-3 Occurrence Handle1:CAS:528:DyaK1cXlslOrsrY%3D Occurrence Handle9727490

    Article  CAS  PubMed  Google Scholar 

  16. K Abravaya B Philips RI Morimoto (1991) ArticleTitleHeat shock-induced interactions of heat shock transcription factor and the human hsp70 promoter examined by in vivo footprinting Mol. Cell Biol. 11 586–592 Occurrence Handle1:CAS:528:DyaK3MXns1WlsA%3D%3D Occurrence Handle1986252

    CAS  PubMed  Google Scholar 

  17. J Rassow K Mohrs S Koidl et al. (1995) ArticleTitleCyclophilin 20 is involved in mitochondrial protein folding in cooperation with molecular chaperones hsp70 and hsp60 Mol. Cell Biol. 15 2654–2662 Occurrence Handle1:CAS:528:DyaK2MXltFagtLo%3D Occurrence Handle7739545

    CAS  PubMed  Google Scholar 

  18. JL Johnson EA Craig (1997) ArticleTitleProtein folding in vivo: unraveling complex pathways Cell 90 201–204 Occurrence Handle10.1016/S0092-8674(00)80327-X Occurrence Handle1:CAS:528:DyaK2sXltVCjtrg%3D Occurrence Handle9244293

    Article  CAS  PubMed  Google Scholar 

  19. L Andreeva R Heads CJ Green (1999) ArticleTitleCyclophilins and their possible role in the stress response Int. J. Exp. Pathol. 80 305–315 Occurrence Handle10.1046/j.1365-2613.1999.00128.x Occurrence Handle1:CAS:528:DC%2BD3cXpvVGitA%3D%3D Occurrence Handle10632780

    Article  CAS  PubMed  Google Scholar 

  20. T Bhattacharyya AN Karnezis SP Murphy et al. (1995) ArticleTitleCloning and subcellular localization of human mitochondrial hsp70 J. Biol. Chem. 270 1705–1710 Occurrence Handle10.1074/jbc.270.4.1705 Occurrence Handle1:CAS:528:DyaK2MXjtlWqurc%3D Occurrence Handle7829505

    Article  CAS  PubMed  Google Scholar 

  21. T Langer W Neupert (1994) Chaperoning mitochondrial biogenesis RM Orimoto A Tissieres CG Georgopoulos (Eds) The Biology of Heat Shock Proteins and Molecular Chaperones Cold Spring Harbor Laboratory Press Cold Spring Harbor, NY 53–83

    Google Scholar 

  22. M Crompton A Costi (1988) ArticleTitleKinetic evidence for a heart mitochondrial pore activated by Ca2+ inorganic phosphate and oxidative stress Eur. J. Biochem. 178 489–501 Occurrence Handle10.1111/j.1432-1033.1988.tb14475.x Occurrence Handle1:CAS:528:DyaL1MXlsFalsg%3D%3D Occurrence Handle2850179

    Article  CAS  PubMed  Google Scholar 

  23. I Marzo C Brenner N Zamzami et al. (1988) ArticleTitleThe permeability transition pore complex: a target for apoptosis regulation by caspases and bcl-2-related proteins J. Exp Med. 187 1261–1271 Occurrence Handle10.1084/jem.187.8.1261

    Article  Google Scholar 

  24. DT Lin JD Lechleiter (2002) ArticleTitleMitochondrial targeted cyclophilin D protects cells from cell death by peptidyl prolyl isomerization J. Biol. Chem. 277 31134–31141 Occurrence Handle10.1074/jbc.M112035200 Occurrence Handle1:CAS:528:DC%2BD38XmsF2js7Y%3D Occurrence Handle12077116

    Article  CAS  PubMed  Google Scholar 

  25. M Capano S Virji M Crompton (2002) ArticleTitleCyclophilin-A is involved in excitotoxin-induced caspase activation in rat neuronal B50 cells Biochem. J. 363 29–36 Occurrence Handle1:CAS:528:DC%2BD38Xjt1aksrY%3D Occurrence Handle11903043

    CAS  PubMed  Google Scholar 

  26. K Woodfield A Ck D Brdiczka et al. (1998) ArticleTitleDirect demonstration of a specific interaction between cyclophilin-D and the adenine nucleotide translocase confirms their role in the mitochondrial permeability transition Biochem. J. 336 287–290 Occurrence Handle1:CAS:528:DyaK1MXhtFSqtQ%3D%3D Occurrence Handle9820802

    CAS  PubMed  Google Scholar 

  27. RA Haworth DR Hunter (1980) ArticleTitleAllosteric inhibition of the Ca2+-activated hydrophilic channel of the mitochondrial inner membrane by nucleotides J. Membr. Biol. 54 231–236 Occurrence Handle1:CAS:528:DyaL3cXltV2isbc%3D Occurrence Handle6248646

    CAS  PubMed  Google Scholar 

  28. AP Halestrap AM Davidson (1990) ArticleTitleInhibition of Ca2+-induced large-amplitude swelling of liver and heart mitochondria by cyclosporin is probably caused by the inhibitor binding to mitochondrial-matrix peptidyl-prolyl cis-trans isomerase and preventing it interacting with the adenine nucleotide translocase Biochem. J. 268 153–160 Occurrence Handle1:CAS:528:DyaK3cXit12nt7Y%3D Occurrence Handle2160810

    CAS  PubMed  Google Scholar 

  29. A Tanveer S Virji L Andreeva et al. (1996) ArticleTitleInvolvement of cyclophilin D in the activation of a mitochondrial pore by Ca2+ and oxidant stress Eur. J. Biochem. 238 166–172 Occurrence Handle10.1111/j.1432-1033.1996.0166q.x Occurrence Handle1:CAS:528:DyaK28Xjt1Krtrw%3D Occurrence Handle8665934

    Article  CAS  PubMed  Google Scholar 

  30. J Xiang DT Chao SJ Korsmeyer (1996) ArticleTitleBAX-induced cell death may not require interleukin 1 beta-converting enzyme-like proteases Proc. Natl. Acad. Sci. U.S.A. 93 14559–14563 Occurrence Handle10.1073/pnas.93.25.14559 Occurrence Handle1:CAS:528:DyaK28XnsVKrtrk%3D Occurrence Handle8962091

    Article  CAS  PubMed  Google Scholar 

  31. JW Montague ML Gaido C Frye et al. (1994) ArticleTitleA calcium dependent nuclease from apoptotic rat thymocytes is homologous with cyclophilin: Recombinant cyclophilin-A, cyclophilin-B, and cyclophilin-C have nuclease activity J. Biol. Chem. 269 18877–18880 Occurrence Handle1:CAS:528:DyaK2cXltVKntbw%3D Occurrence Handle8034643

    CAS  PubMed  Google Scholar 

  32. DH Walter J Haendeler J Galle et al. (1998) ArticleTitleCyclosporin A inhibits apoptosis of human endothelial cells by preventing release of cytochrome C from mitochondria Circulation 98 1153–1157 Occurrence Handle1:CAS:528:DyaK1cXmtlOmtbc%3D Occurrence Handle9743504

    CAS  PubMed  Google Scholar 

  33. G Kroemer P Petit N Zamzami et al. (1995) ArticleTitleThe biochemistry of programmed cell death FASEB J. 9 1277–1287 Occurrence Handle1:CAS:528:DyaK2MXovVGnsb0%3D Occurrence Handle7557017

    CAS  PubMed  Google Scholar 

  34. P Li D Nijhawan I Budihardjo et al. (1997) ArticleTitleCytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade Cell 91 479–489 Occurrence Handle10.1016/S0092-8674(00)80434-1 Occurrence Handle1:CAS:528:DyaK2sXnsFGls70%3D Occurrence Handle9390557

    Article  CAS  PubMed  Google Scholar 

  35. G Wiederecht E Lam S Hung et al. (1993) ArticleTitleThe mechanism of action of FK-506 and cyclosporin A Ann. NY Acad. Sci. 696 9–19 Occurrence Handle7509138

    PubMed  Google Scholar 

  36. JD Molkentin JR Lu CL Antos et al. (1998) ArticleTitleA calcineurin-dependent transcriptional pathway for cardiac hypertrophy Cell 93 215–228 Occurrence Handle10.1016/S0092-8674(00)81573-1 Occurrence Handle1:CAS:528:DyaK1cXivVygtrs%3D Occurrence Handle9568714

    Article  CAS  PubMed  Google Scholar 

  37. J Liu JD Farmer WA Lane et al. (1991) ArticleTitleCalcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes Cell 66 807–815 Occurrence Handle10.1016/0092-8674(91)90124-H Occurrence Handle1:CAS:528:DyaK3MXlsV2qu7w%3D Occurrence Handle1715244

    Article  CAS  PubMed  Google Scholar 

  38. DA Fruman CB Klee BE Bierer et al. (1992) ArticleTitleCalcineurin phosphatase activity in T lymphocytes is inhibited by FK506 and cyclosporin A Proc. Natl. Acad Sci. U.S.A. 89 3686–3690 Occurrence Handle1:CAS:528:DyaK38Xkt1SisLo%3D Occurrence Handle1373887

    CAS  PubMed  Google Scholar 

  39. SN Sehgal K Molnar-Kinber TD Ocain et al. (1994) ArticleTitleRapamycin: a novel immunosuppressive macrolide Med. Res. Rev. 14 1–12 Occurrence Handle1:CAS:528:DyaK2cXhsFaktrY%3D Occurrence Handle8309312

    CAS  PubMed  Google Scholar 

  40. XX Zheng TB Strom AW Steele (1994) ArticleTitleQuantitative comarison of rapamycin and cyclosporin effects on cytokine gene expression studied by reverse transcriptase-competitive polymerase chain reaction Transplantation 276 63–66

    Google Scholar 

  41. RJ Bram GR Crabtree (1994) ArticleTitleCalcium signalling in T cells stimulated by a cyclophilin B-binding protein Nature 297 365–372

    Google Scholar 

  42. ME Cardenas C Hemenway RS Muir et al. (1994) ArticleTitleImmunophilins interact with calcineurin in the absence of exogenous immunosupperssive ligands EMBO J. 13 5944–5957 Occurrence Handle1:CAS:528:DyaK2MXivFKgtLk%3D Occurrence Handle7529175

    CAS  PubMed  Google Scholar 

  43. F Allain C Vanpouille M Carpentier et al. (2002) ArticleTitleInteraction with glycosaminoglycans is reguired for cyclophilin B to trigger integrin-mediated adhesion of peripheral blood T lymphocytes to extracellular matrix Proc. Natl. Acad. Sci. U.S.A. 99 2714–2719 Occurrence Handle1:CAS:528:DC%2BD38Xit1Crtr0%3D Occurrence Handle11867726

    CAS  PubMed  Google Scholar 

  44. B Sherry N Yarlett A Strupp et al. (1992) ArticleTitleIdentification of cyclophilin as a proinflammatry secretory product of lipopolysaccharide-activated macrophages Proc. Natl. Acad. Sci. U.S.A. 89 3511–3515 Occurrence Handle1:CAS:528:DyaK38XisFeku74%3D Occurrence Handle1565646

    CAS  PubMed  Google Scholar 

  45. V Yurchenko G Zybarth M O’Connor et al. (2002) ArticleTitleActive site redisues of cyclophilin A are crucial for its signalling activity via CFD 147 J. Biol. Chem. 277 22959–22965 Occurrence Handle1:CAS:528:DC%2BD38XltVGrs78%3D Occurrence Handle11943775

    CAS  PubMed  Google Scholar 

  46. B Sherry G Zybarth M Alfano et al. (1998) ArticleTitleRole of cyclophilin A in the uptake of HIV-a by macrophages and T lymphocytes Proc. Natl Acad. Sci. U.S.A. 95 1758–1763 Occurrence Handle1:CAS:528:DyaK1cXht1Wqu7w%3D Occurrence Handle9465090

    CAS  PubMed  Google Scholar 

  47. ZG Jin MG Melaragno DF Liao et al. (2000) ArticleTitleCyclophilin A is a secreted growth factor induced by oxidative stress Circ. Res. 87 789–796 Occurrence Handle1:CAS:528:DC%2BD3cXnvVOlu7g%3D Occurrence Handle11055983

    CAS  PubMed  Google Scholar 

  48. V Yurchenko M O’Connor WW Dai et al. (2001) ArticleTitleCD147 is a signaling receptor for cyclophilin B Biochem. Biophys. Res. Commun. 288 786–788 Occurrence Handle1:CAS:528:DC%2BD3MXnvFGisL8%3D Occurrence Handle11688976

    CAS  PubMed  Google Scholar 

  49. F Berditchevski S Chang J Bodorova et al. (1997) ArticleTitleGeneration of monoclonal antibodies to integrin-associated proteins: Evidence that a3bl complexes with EMMRRIN/basignin/OX47/M6 J. Biol. Chem 272 29174–29180 Occurrence Handle1:CAS:528:DyaK2sXnsVOiur4%3D Occurrence Handle9360995

    CAS  PubMed  Google Scholar 

  50. YT Konttinen TF Li J Mandelin et al. (2000) ArticleTitleIncreased expression of extracelluluar matrix metalloproteinase induce in rheumatoid synonium: increased expression of extracellular matrix metalloproteinase inducer in rheumatoid synovium Arthritis Rheum. 43 275–280 Occurrence Handle1:CAS:528:DC%2BD3cXhs1aqtLo%3D Occurrence Handle10693866

    CAS  PubMed  Google Scholar 

  51. BR Howard FF Vajdos S Li et al. (2003) ArticleTitleStructural insights into the catalytic mechanism of cyclophilin A Nat. Struct. Biol. 10 475–481 Occurrence Handle1:CAS:528:DC%2BD3sXjvF2ktrc%3D Occurrence Handle12730686

    CAS  PubMed  Google Scholar 

  52. AC Saphire MD Bobardt PA Gallay (1999) ArticleTitleHost cyclophilin A mediates HIV-1 attachment to target cells via heparans EMBO J. 18 6771–6785 Occurrence Handle1:CAS:528:DC%2BD3cXhslyjtg%3D%3D Occurrence Handle10581250

    CAS  PubMed  Google Scholar 

  53. GJ Towers T Hatziioannou S Cowan et al. (2003) ArticleTitleCyclophilin A modelates the sensitivity of HIV-1 to host restriction factors Nat. Med. 9 1138–1143 Occurrence Handle1:CAS:528:DC%2BD3sXmvVWnsr4%3D Occurrence Handle12897779

    CAS  PubMed  Google Scholar 

  54. BK Ward PJ Mark DM Ingram et al. (1999) ArticleTitleExpression of the estrogen receptor-associated immunophilins, cyclophilin 40 and FKBP52, in breast cancer Breast Cancer Res. Treat. 58 267–280 Occurrence Handle1:CAS:528:DC%2BD3cXitVenur0%3D Occurrence Handle10718488

    CAS  PubMed  Google Scholar 

  55. PJ Mark BK Ward P Kumar et al. (2001) ArticleTitleHuman cyclophilin 40 is a heat shock protein that exhibits altered intracellular localization following heat shock Cell Stress Chaperones 6 59–70 Occurrence Handle1:CAS:528:DC%2BD3MXjtFWqtrs%3D Occurrence Handle11525244

    CAS  PubMed  Google Scholar 

  56. SD Hursting JC Shen XY Sun et al. (2002) ArticleTitleModulation of cyclophilin gene expression by N-4-(hydroxyphenyl)retinamide: association with reactive oxygen species generation and apoptosis Mol. Carcinog. 33 16–24 Occurrence Handle1:CAS:528:DC%2BD38Xmt1yjtw%3D%3D Occurrence Handle11807954

    CAS  PubMed  Google Scholar 

  57. P Kumar PJ Mark BK Ward et al. (2001) ArticleTitleEstradiol-regulated expression of the immunophilins cyclophilin 40 and FKBP52 in MCF-7 breast cancer cells Biochem. Biophys. Res. Commun. 284 219–225 Occurrence Handle1:CAS:528:DC%2BD3MXjslyitLg%3D Occurrence Handle11374893

    CAS  PubMed  Google Scholar 

  58. BK Ward P Kumar GR Turbett et al. (2001) ArticleTitleAllelic loss of cyclophilin 40, an estrogen receptor-associated immunophilin, in breast carcinomas J. Cancer Res. Clin. Oncol. 127 109–115 Occurrence Handle1:CAS:528:DC%2BD3MXjs1Kmtw%3D%3D Occurrence Handle11216911

    CAS  PubMed  Google Scholar 

  59. MJ Campa MZ Wang B Howard et al. (2003) ArticleTitleProtein expression profiling identifies macrophage migration inhibitory factor and cyclophilin a as potential molecular targets in non-small cell lung cancer Cancer Res. 63 1652–1656 Occurrence Handle1:CAS:528:DC%2BD3sXisFaiu7c%3D Occurrence Handle12670919

    CAS  PubMed  Google Scholar 

  60. S Gomi M Nakao F Niiya et al. (1999) ArticleTitleA cyclophilin B gene encodes antigenic epitopes recognized by HLA-A24-restricted and tumor-specific CTLs J. Immunol. 163 4994–5004 Occurrence Handle1:CAS:528:DyaK1MXmvFajtbw%3D Occurrence Handle10528204

    CAS  PubMed  Google Scholar 

  61. R Gohara N Imai T Rikimaru et al. (2002) ArticleTitlePhase 1 clinical study of cyclophilin B peptide vaccine for patients with lung cancer J. Immunother. 25 439–444 Occurrence Handle1:CAS:528:DC%2BD38XntlyhtLw%3D Occurrence Handle12218782

    CAS  PubMed  Google Scholar 

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Acknowledgments

This work was supported by National Institutes of Health grants R01 HL61943 (C.C.), R01 HL60135 (C.C.), R01 HL65916 (C.C.), R01 HL72716 (C.C.), R01 EB-002436 (C.C.), Methodist 39935 (M.L.), K08 CA85822 (W.F.), R13 CA101889 (F.C.B.), R21 AI 49116 (Q.Y.), and R01 DE015543 (Q.Y.).

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  1. Molecular Surgeon Research Center, Michael E. DeBakey Department of Surgery, Baylor College of Medicine and The Methodist Hospital, 6550 Fannin Street, Houston, Texas 77030, USA

    Qizhi Yao M.D., Ph.D., Min Li Ph.D., Hui Yang M.D., Ph.D., Hong Chai M.D., Ph.D., William Fisher M.D. & Changyi Chen M.D., Ph.D.

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  1. Qizhi Yao M.D., Ph.D.
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  2. Min Li Ph.D.
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Correspondence to Changyi Chen M.D., Ph.D..

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Yao, Q., Li, M., Yang, H. et al. Roles of Cyclophilins in Cancers and Other Organ Systems. World J. Surg. 29, 276–280 (2005). https://doi.org/10.1007/s00268-004-7812-7

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