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Laparoscopic Cholecystectomy: Its Effect on the Prognosis of Patients with Gallbladder Cancer

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Abstract

Numerous reports suggest more recurrences and a worse prognosis after laparoscopic cholecystectomy (LC) than after open cholecystectomy (OC). The objective of this study was to compare the survival rate of patients undergoing a laparoscopic procedure versus those undergoing an open operation. A series of 24 patients with gallbladder cancer detected after LC were compared with 40 consecutive patients with gallbladder cancer detected after OC. Patients were matched by wall invasion, age, and whether they underwent a reoperation or only cholecystectomy. The series included 2 patients with in situ tumors, 2 with mucosal tumors, 1 with muscular invasion, 13 with subserosal invasion, and 6 with serosal invasion. Recurrences were observed in 4 of the 10 patients with subserosal compromise who underwent reoperation. In contrast, in the OC group of 26 patients with subserosal invasion, 20 of whom were reoperated, only 2 had a recurrence. Of the six patients with serosal infiltration, three in the LC underwent reoperation, all of whom had recurrences that precluded resection. Of the 12 patients in the OC group who presented with serosal invasion, 6 were reoperated and 4 had a recurrence. Overall survival curves did not show differences when patients were compared according to the type of procedure performed. Similarly, the analysis of patients according to the level of wall invasion indicated that there was no significant difference in survival. Although multiple reports have shown a worse prognosis for patients with gallbladder cancer undergoing LC, this study did not show a significant survival difference between the two methods. Although there is a higher but insignificant recurrence rate among the patients who underwent LC, this is not translated into survival.

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References

  1. X Aretxabala ParticleDe I Roa L Burgos et al. (1997) ArticleTitleCurative resection in potentially resectable tumors of the gallbladder Eur. J. Surg. 163 419–426 Occurrence Handle9231853

    PubMed  Google Scholar 

  2. S Benoist Y Panis PL Fagniez et al. (1998) ArticleTitleLong term results after curative resection for carcinoma of the gallbladder Am. J. Surg. 175 119–122 Occurrence Handle10.1016/S0002-9610(97)00269-9

    Article  Google Scholar 

  3. I Serra (2001) ArticleTitleHa disminuido la mortalidad por cáncer vesicular en Chile? Rev. Med. Chile 129 1079–1084 Occurrence Handle1:STN:280:DC%2BD3MnnvFKmuw%3D%3D Occurrence Handle11725474

    CAS  PubMed  Google Scholar 

  4. Y Shirai K Yoshida K Tsukada et al. (1992) ArticleTitleRadical resection for gallbladder carcinoma: long term results Ann. Surg. 16 565–568

    Google Scholar 

  5. CC Nduka JRT Monson N Menzies-Gow et al. (1994) ArticleTitleAbdominal wall metastases following laparoscopy Br. J. Surg. 81 648–652 Occurrence Handle1:STN:280:ByuA3MbnvFI%3D Occurrence Handle8044537

    CAS  PubMed  Google Scholar 

  6. DG Clair DB Lautz DC Brooks et al. (1993) ArticleTitleRapid development of umbilical metastases after laparoscopic cholecystectomy for unsuspected gallbladder carcinoma Surgery 113 355–358 Occurrence Handle1:STN:280:ByyC1c7otVM%3D Occurrence Handle7772085

    CAS  PubMed  Google Scholar 

  7. Y Fong M Brennan A Turnbull et al. (1993) ArticleTitleGallbladder cancer discovered during laparoscopic cholecystectomy: potential for iatrogenic tumor dissemination Arch. Surg. 128 1054–1056 Occurrence Handle1:STN:280:ByyA2sfltlw%3D Occurrence Handle8368924

    CAS  PubMed  Google Scholar 

  8. P Hermanek RVP Hutter LH Sobin et al. (1997) UICC TNM Atlas EditionNumber4th edition Springer-Verlag New York

    Google Scholar 

  9. X Aretxabala ParticleDe I Roa L Burgos et al. (1992) ArticleTitleGallblader cancer in chile: a report on 54 potentially resectable tumors Cancer 69 60–65 Occurrence Handle1727676

    PubMed  Google Scholar 

  10. X Aretxabala ParticleDe I Roa L Burgos et al. (1999) ArticleTitlePreoperative chemoradiotherapy in the treatment of gallbladder cancer Am. Surg. 65 241–246 Occurrence Handle10075301

    PubMed  Google Scholar 

  11. RB Fahim JR McDonald JC Richards et al. (1962) ArticleTitleCarcinoma of the gallbladder: a study of its methods of spread Ann. Surg. 156 114–124 Occurrence Handle1:STN:280:CC2D3s3mtlc%3D Occurrence Handle13891308

    CAS  PubMed  Google Scholar 

  12. AE Ricardo BW Feig LM Ellis et al. (1997) ArticleTitleGallbladder cancer and tocar site recurrences Am. J. Surg. 174 619–622 Occurrence Handle10.1016/S0002-9610(97)00178-5 Occurrence Handle1:STN:280:DyaK1c%2Fnt1ansQ%3D%3D Occurrence Handle9409585

    Article  CAS  PubMed  Google Scholar 

  13. K Z’graggen S Birrer CA Maurer et al. (1998) ArticleTitleIncidence of port site recurrence after laparoscopic cholecystectomy for preoperatively unsuspected gallbladder carcinoma Surgery 124 831–838 Occurrence Handle10.1067/msy.1998.90364 Occurrence Handle1:STN:280:DyaK1M%2FktVOhuw%3D%3D Occurrence Handle9823395

    Article  CAS  PubMed  Google Scholar 

  14. K Suzuki T Kimura H Ogawa (1998) ArticleTitleIs laparoscopic cholecystectomy hazardous for gallbladder cancer Surgery 123 311–314 Occurrence Handle10.1067/msy.1998.85938 Occurrence Handle1:STN:280:DyaK1c7oslaksw%3D%3D Occurrence Handle9526523

    Article  CAS  PubMed  Google Scholar 

  15. LA Wibbenmeyer TP Wade RC Chen et al. (1995) ArticleTitleLaparoscopic cholecystectomy can disseminate in situ carcinoma of the gallbladder J. Am. Coll. Surg. 181 504–510 Occurrence Handle1:STN:280:BymD1MrhtlA%3D Occurrence Handle7582223

    CAS  PubMed  Google Scholar 

  16. M Doudle G King WM Thomas et al. (1996) ArticleTitleThe movement of mucosal cells of the galbladder within the peritoneal cavity during laparoscopic cholecystectomy Surg. Endosc. 10 1092–1094 Occurrence Handle10.1007/s004649900247 Occurrence Handle1:STN:280:ByiD2crgs1c%3D Occurrence Handle8881059

    Article  CAS  PubMed  Google Scholar 

  17. G Champault N Taffinder M Ziol et al. (1997) ArticleTitleCells are present in the smoke created during laparoscopic surgery Br. J. Surg. 84 993–995 Occurrence Handle1:STN:280:ByiA1cvkslM%3D Occurrence Handle9240145

    CAS  PubMed  Google Scholar 

  18. JS Wu EB Brasfield LW Guo et al. (1997) ArticleTitleImplantation of colon cancer at trocar sites is increased by low pressure pneumoperitoneum Surgery 122 1–7 Occurrence Handle10.1016/S0039-6060(97)90256-7 Occurrence Handle1:STN:280:ByiA28bktF0%3D Occurrence Handle9225907

    Article  CAS  PubMed  Google Scholar 

  19. ND Bouvy RL Marquet J Jeekel et al. (1997) ArticleTitleLaparoscopic surgery is associated with less tumor growth stimulation than conventional surgery: an experimental study Br. J. Surg. 84 358–361 Occurrence Handle10.1046/j.1365-2168.1997.02590.x Occurrence Handle1:STN:280:ByiB3s3ht1I%3D Occurrence Handle9117307

    Article  CAS  PubMed  Google Scholar 

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Acknowledgments.

This study was supported by grant 1010523 from Fondecyt Chile.

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Authors and Affiliations

  1. Department of Surgery, Universidad de la Frontera, German Clinic Temuco, PO Box 54-D, Temuco 4781176, Chile

    Xabier A. de Aretxabala M.D., Javier P. Mora M.D., Luis A. Burgos M.D. & Alvaro J. Cuadra M.D.

  2. Pathology Unit, Universidad de la Frontera, PO Box 54-D, Temuco 4781176, Chile

    Ivan S. Roa M.D.

  3. Epidemiology Unit, Universidad de la Frontera, PO Box 54-D, Temuco 4781176, Chile

    Juan J Orellana & Juan P. Riedeman M.D.

  4. Department of Surgery, Hospital Quilpue, San Martin 1270, Quilpue 6540562, Chile

    Veronica P. Silva M.D.

  5. Department of Surgery, Roger Williams Medical University, Boston University, 825 Chalkstone Avenue, 02908, Providence, Rhode Island, USA

    Harold J. Wanebo M.D.

Authors
  1. Xabier A. de Aretxabala M.D.
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  2. Ivan S. Roa M.D.
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  3. Javier P. Mora M.D.
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  4. Juan J Orellana
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  5. Juan P. Riedeman M.D.
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  6. Luis A. Burgos M.D.
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  7. Veronica P. Silva M.D.
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  8. Alvaro J. Cuadra M.D.
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  9. Harold J. Wanebo M.D.
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Correspondence to Xabier A. de Aretxabala M.D..

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de Aretxabala, X., Roa, I., Mora, J. et al. Laparoscopic Cholecystectomy: Its Effect on the Prognosis of Patients with Gallbladder Cancer. World J. Surg. 28, 544–547 (2004). https://doi.org/10.1007/s00268-004-6886-6

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  • DOI: https://doi.org/10.1007/s00268-004-6886-6

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