Abstract
Background
Hyaluronic acid is the most popular dermal filler in the treatment of nasolabial folds. Injection methods vary among physicians.
Methods
A randomized, two-center, double-blind, intraindividual trial was designed to compare a new method of injecting ART FILLER® UNIVERSAL using the retaining ligament with the traditional method (linear threading and bolus injection) in moderate to severe nasolabial folds. Forty patients with moderate to severe nasolabial folds were randomized into groups A and B. Group A received injections via the traditional method on the left side and the ligament method on the right side, while group B received the reverse. Clinical efficacy and patient safety were independently assessed by a blinded evaluator, the injector, using the Wrinkle Severity Rating Scale (WSRS), the Global Aesthetic Improvement Scale (GAIS), and the Medicis Midface Volume Scale (MMVS) at 4 weeks (before and after the touch-up injection), 8 weeks, 12 weeks, and 24 weeks after the baseline injection.
Results
From the perspective of the blinded evaluator, the improvements in WSRS scores from baseline did not differ significantly between the ligament method (0.73 ± 0.61) and the traditional method (0.89 ± 0.61) at week 24 (p > 0.05). The mean GAIS score at week 24 was 1.41 ± 0.49 for the traditional method and 1.32 ± 0.47 for the ligament method (p > 0.05).
Conclusions
The efficacy and safety of the ligament method for the management of nasolabial folds are comparable to those of the traditional method in terms of WSRS and GAIS score improvement in the long run. The ligament method is superior to the traditional method in that it improves midface deficits with fewer adverse events.
Level of Evidence II
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Clinical Trial Registration: This study was registered with the Chinese Clinical Trial Registry under the registration number ChiCTR2100041702.
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Acknowledgements
This clinical trial was supported by Jiessie (Beijing) Biological Technology Co., Ltd.
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The study was approved by the independent ethics committees of two centers in Guangdong and Sichuan, People's Republic of China (Guangdong Second Provincial General Hospital and West China Hospital of Stomatology, Sichuan University).
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Feng, G., Peng, T., Hong, WJ. et al. A Two-Center, Prospective, Randomized Controlled Trial to Evaluate the Efficacy and Safety of and Satisfaction with Different Methods of ART FILLER® UNIVERSAL Injection for Correcting Moderate to Severe Nasolabial Folds in Chinese Individuals. Aesth Plast Surg 47, 1550–1559 (2023). https://doi.org/10.1007/s00266-023-03278-2
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DOI: https://doi.org/10.1007/s00266-023-03278-2