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Rhinofiller: Fat Grafting (Surgical) Versus Hyaluronic Acid (Non-Surgical)

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  • Rhinoplasty
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Abstract

Background

The author presented his experience using "fat grafting" (FG) and "hyaluronic acid" (HA) techniques in nasal remodeling.

Objectives

The paper aimed to evaluate the efficacy and safety of the use of FG and HA in nasal remodeling for aesthetic improvement.

Methods

A randomized controlled trial was conducted. 15 patients affected by soft defects of the dorsum, low and boxy nasal tip, and hidden columella, were treated with FG (study group—SG), comparing results with the control group (CG) (n = 17) treated with hyaluronic acid (HA). Post-operative follow-up took place at 1, 2, 4, weeks, 3, 6, 12 months, and then annually.

Results

73.7% of SG patients showed excellent cosmetic results after 1 year compared with only 29.7% of CG patients. At one-month, major part of people who underwent the treatments (FG and HA) referred to satisfaction with the resulting volume contours (p = 0.389). 88.3% of CG patients versus 53.8% of SG described the HA and FG injection, respectively, as a very comfortable and non-invasive procedure. As expected, patient satisfaction with the appearance of nasal contouring was higher in the FG group at 1 year.

Conclusions

FG and HA were safe and effective in this series of cases performed.

Level of evidence III

This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266.

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Funding

The author received no financial support for this article’s research, authorship, and publication.

Author information

Authors and Affiliations

  1. Department of Surgical Science, “Tor Vergata” University, Via Montpellier 1, 00133, Rome, Italy

    Pietro Gentile

  2. Academy of International Regenerative Medicine and Surgery Societies (AIRMESS), 1201, Geneva, Switzerland

    Pietro Gentile

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  1. Pietro Gentile
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Contributions

PG designed the studies, performed the procedures, analyzed the results, wrote the paper, wrote an editing review, dealt with methodology and validation, performed the data analysis, and conducted the study as the leader.

Corresponding author

Correspondence to Pietro Gentile.

Ethics declarations

Conflict of interest

The author declared no potential conflicts of interest concerning the research, authorship, and publication of this article.

Ethical Approval

The study protocol, which was the object of two university master's degrees titled "Plastic Aesthetic Surgery of Facial District" and “Regenerative Surgery and Medicine in Wound Care Management”, was approved with Rectoral Decree (D.R. n. 1794/2018) of September 19, 2018, and the Ethics on Research Committee of the School of Medicine, “Tor Vergata” University, Rome, Italy, with registration number #0031036/2018. All the patients received detailed oral and written information about the study, including the risks, benefits, and alternative therapies, and signed an informed consent form and a photo-release form before any study procedures. Additionally, about the FG, the protocols adopted were performed following the European rules (1394/2007 EC) and EMA/CAT recommendations (20 June 2014 EMA/CAT/600280/2010 Rev 1). The study has been developed in agreement with research contract #1467/2017 and associate professor contract #13489/2021 between the first author P.G., and the University of Rome “Tor Vergata”, Italy.

Informed Consent

All participants provided informed consent.

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Gentile, P. Rhinofiller: Fat Grafting (Surgical) Versus Hyaluronic Acid (Non-Surgical). Aesth Plast Surg 47, 702–713 (2023). https://doi.org/10.1007/s00266-022-03209-7

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  • DOI: https://doi.org/10.1007/s00266-022-03209-7

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