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Organoids and Their Research Progress in Plastic and Reconstructive Surgery

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Abstract

Organoids are 3D structures generated from stem cells. Their functions and physiological characteristics are similar to those of normal organs. They are used in disease mechanism research, new drug development, organ transplantation and other fields. In recent years, the application of 3D materials in plastic surgery for repairing injuries, filling, tissue reconstruction and regeneration has also been investigated. The PubMed/MEDLINE database was queried to search for animal and human studies published through July of 2022 with search terms related to Organoids, Plastic Surgery, Pluripotent Stem Cells, Bioscaffold, Skin Reconstruction, Bone and Cartilage Regeneration. This review presents stem cells, scaffold materials and methods for the construction of organoids for plastic surgery, and it summarizes their research progress in plastic surgery in recent years.

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Funding

This work was supported by the National Nature Science Foundation of China (No. 81873939)

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  1. Huiting Wu and Guanhuier Wang have been contributed equally to this work.

Authors and Affiliations

  1. Department of Plastic Surgery, Peking University Third Hospital, Haidian District, 49 North Garden Road, Beijing, 100191, China

    Huiting Wu, Guanhuier Wang, Yujia Shang, Na Liu, Yonghuan Zhen & Yang An

  2. Department of Natural Products Chemistry, School of Traditional Chinese Materia Medica, Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang, 110016, China

    Huiting Wu, Yujia Shang, Na Liu, Lixia Chen & Hua Li

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  1. Huiting Wu
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  2. Guanhuier Wang
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  7. Hua Li
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Wu, H., Wang, G., Shang, Y. et al. Organoids and Their Research Progress in Plastic and Reconstructive Surgery. Aesth Plast Surg 47, 880–891 (2023). https://doi.org/10.1007/s00266-022-03129-6

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