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The survival and prognosis analysis of synovial sarcoma subtypes: a Surveillance, Epidemiology, and End Results population-based analysis

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Abstract

Purpose

By comparing epidemiologic and prognostic data of synovial sarcoma subtypes, this study aims to clarify the difference in prognosis and risk factors among different synovial sarcoma subtypes.

Methods

In total, 1692 patients with synovial sarcoma in the USA who were diagnosed during 1975 through 2016 and retrieved from the Surveillance, Epidemiology, and End Results (SEER) program were studied.

Results

There were statistically significant differences in the distribution of age and race among three synovial sarcoma subtypes, while no major differences in the distribution of sex, tumor stage, and tumour size were found. The highest five and ten year survival rates were found in the biphasic subtype (69%, 60%), followed by the monophasic subtype (59%, 49%), and lowest in the epithelioid subtype (32%, 26%). Age and SEER historic stage were the two demographic factors that found to have statistically significant impact on survival in all subtypes. Radiation was found to be protective in the monophasic subtype (HR 0.61, p < 0.001).

Conclusion

Among different synovial sarcoma subtypes, the biphasic subtype favoured the best survival, while the epithelioid cell subtype was associated with the worst. Male and black race were independently associated with worse survival only in the monophasic subtype. Radiotherapy could provide significant benefit for patients with the monophasic synovial sarcoma.

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Authors and Affiliations

  1. Department of Orthopedics, The Second Xiangya Hospital of Central South University, Changsha, 410011, Hunan, China

    Liang Xiong, Zhuoyuan Chen, You Zhou, Hui Li & Tao Xiao

  2. Orthopedic Biomedical Materials Engineering Laboratory of Hunan Province, Changsha, 410011, Hunan, China

    Liang Xiong, Zhuoyuan Chen, You Zhou, Hui Li & Tao Xiao

  3. Orthopedic Biomedical Materials Institute of Central South University, Changsha, 410011, Hunan, China

    Tao Xiao

Authors
  1. Liang Xiong
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  2. Zhuoyuan Chen
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  3. You Zhou
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  4. Hui Li
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  5. Tao Xiao
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Contributions

All authors made contributions to the research design, data collection, statistical analysis, and reporting for this manuscript. All authors have read and approved the final submitted manuscript.

Corresponding authors

Correspondence to Hui Li or Tao Xiao.

Ethics declarations

All data were extracted from the SEER database, and no additional Institutional Review Board approval was needed for this study.

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The authors declare that they have no conflict of interest.

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Level of Evidence III, Retrospective Cohort Study

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ESM 1

(a) Kaplan-Meier survival analysis of the epithelioid cell subtype according to Patients’ age. (b) Kaplan-Meier survival analysis of the epithelioid cell subtype according to SEER historic stage. (PNG 3049 kb)

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Xiong, L., Chen, Z., Zhou, Y. et al. The survival and prognosis analysis of synovial sarcoma subtypes: a Surveillance, Epidemiology, and End Results population-based analysis. International Orthopaedics (SICOT) 44, 2779–2786 (2020). https://doi.org/10.1007/s00264-020-04708-5

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