Skip to main content

Advertisement

SpringerLink
Log in

Adult multifocal pigmented villonodular synovitis—clinical review

  • Review Article
  • Published:
International Orthopaedics Aims and scope Submit manuscript

Abstract

Pigmented villonodular synovitis (PVNS) is a rare, benign proliferative disease of the synovial tissue that affects a single joint or a tendon sheath. Data from the literature present only a few cases of multifocal PVNS. This paper presents multifocal PVNS in the adult. This disease can affect bilateral shoulders, hips and knees. The diagnosis may be delayed by the slow evolution of the disease (up to ten years); some patients may be seen with late-stage degenerative joints, serious complications, painful and functionally uncompensated, with significant locomotion deficit. PVNS requires a radical treatment with prosthetic arthroplasty associated with synovectomy. Complex imaging (X-Rays, magnetic resonance imaging (MRI), ultrasound) and macroscopic appearance of the lesions during surgery confirms the clinical diagnosis of multifocal PVNS with secondary bone lesions. Histology marks the final diagnosis of multifocal PVNS. The postoperative results are good, with recovery in functional parameters of the joints with endoprosthesis.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3
Fig. 4
Fig. 5

Similar content being viewed by others

References

  1. Byers PD, Cotton RE, Deacon UW (1968) The diagnosis and treatment of pigmented villonodular synovitis. J Bone Joint Surg Am 50:290–305

    CAS  Google Scholar 

  2. Smith JH, Pugh DG (1962) Roentgenographic aspects of articular pigmented villonodular synovitis. AJR Am J Roentgenol 87:1146–1156

    CAS  Google Scholar 

  3. Jaffe HL, Lichtenstein L, Sutro CJ (1941) Pigmented villonodular synovitis, bursitis, and tenosynovitis. Arch Pathol 31:731–765

    Google Scholar 

  4. Myers BW, Masi AT (1980) Pigmented villonodular synovitis and tenosynovitis: a clinical epidemiologic study of 166 cases and literature review. Medicine 59:2030–2036

    Article  Google Scholar 

  5. Nilsonne U, Moberger G (1969) Pigmented villonodular synovitis of joints. Acta Orthop Scand 40:448–460

    Article  PubMed  CAS  Google Scholar 

  6. Gehweiler JA, Wilson JW (1969) Diffuse biarticular pigmented villonodular synovitis. Radiology 93:845–850

    PubMed  CAS  Google Scholar 

  7. Eisenberg RL, Hedgcock MW (1978) Bilateral pigmented villonodular synovitis of the hip. Br J Radiol 51:916–917

    Article  PubMed  CAS  Google Scholar 

  8. Jamieson TW, Curran JJ, Desmet AA, Cotelingam JD, Kimmich H (1990) Bilateral pigmented villonodular synovitis of the wrists. Orthop Rev 19:432–436

    PubMed  CAS  Google Scholar 

  9. Zuber M, Braun C, Pfreundschuh M, Piischel W (1996) Ulnar deviation is not always rheumatoid. Ann Rheum Dis 55:786–788

    Article  PubMed  CAS  Google Scholar 

  10. Cotten A, Flipo RM, Chastanet P, Desvigne-Noulet MC, Duquesnoy B, Delcambre B (1995) Pigmented villonodular synovitis of the hip: review of radiographic features in 58 patients. Skeletal Radiol 24(1):1–6

    Article  PubMed  CAS  Google Scholar 

  11. Lee M, Mahroof S, Pringle J, Short SC, Briggs TW, Cannon SR (2005) Diffuse pigmented villonodular synovitis of the foot and ankle treated with surgery and radiotherapy. Int Orthop 29(6):403–405

    Article  PubMed  CAS  Google Scholar 

  12. Koh KH, Lim KS, Yoo JC (2010) Arthroscopic treatment of pigmented villonodular synovitis involving bilateral shoulders. Orthopedics 33(6):442

    PubMed  Google Scholar 

  13. Kim HS, Kwon JW, Ahn JH, Chang MJ, Cho EY (2010) Localized tenosynovial giant cell tumor in both knee joints. Skeletal Radiol 39(9):923–926

    Article  PubMed  Google Scholar 

  14. Akinci O, Akalin Y, Kayali C (2012) Results of total knee arthroplasty in patients with gonarthrosis resulting from the delayed diagnosis of PVNS: a case series. Eur J Orthop Surg Traumatol 22:51–56

    Article  Google Scholar 

  15. Graf J, Bernd L, Pauschert R, Niethard FU (1991) Rare occurrence of villonodular synovitis of both shoulder joints. Z Rheumatol 50(1):46–48

    PubMed  CAS  Google Scholar 

  16. Patkar D, Prasad S, Shah J, Patankar T, Kothari S (2000) Pigmented villonodular synovitis: magnetic resonance features of an unusual case of bilateral hip joint involvement. Australas Radiol 44(4):458–459

    Article  PubMed  CAS  Google Scholar 

  17. Krause FG, Wroblewski JA, Younger AS (2009) Pigmented villonodular synovitis in both hindfeet. Can J Surg 52(2):E38–E39

    PubMed  Google Scholar 

  18. Mukhopadhyay K, Smith M, Hughes PM (2006) Multifocal PVNS in a child—followed over 25 years. Skeletal Radiol 35:539–542

    Article  PubMed  Google Scholar 

  19. Leszczynski J, Huckell JR, Percy JS, LeRiche JC, Lentle BC (1975) Pigmented villonodular synovitis in multiple joints. Ann Rheum Dis 34:269–272

    Article  PubMed  CAS  Google Scholar 

  20. Walls JP, Nogi J (1985) Multifocal pigmented villonodular synovitis in a child. Casereport. J Pediatr Orthop 5:229–231

    PubMed  CAS  Google Scholar 

  21. Martin RC II, Osborne DL, Edwards MJ, Wrightson W, McMasters KM (2000) Giant cell tumor of tendon sheath, tenosynovial giant cell tumor, and pigmented villonodular synovitis: defining the presentation, surgical therapy and recurrence. Oncol Rep 7(2):413–419

    PubMed  Google Scholar 

  22. Pavlica L, Nikolic D, Tadic J, Tatic V, Bralovic S, Panajotovic L (1997) Pigmented villonodular synovitis—analysis of 50 patients. Vojnosanit Pregl 543:209–216

    Google Scholar 

  23. Kay RM, Eckardt JJ, Mirra JM (1996) Multifocal pigmented villonodular synovitis in a child: a case report. Clin Orthop Relat Res 322:194–197

    Article  PubMed  Google Scholar 

  24. Vedantam R, Strecker WB, Schoenecker PL, Salinas-Madrigal L. (1998) Polyarticular pigmented villonodular synovitis in a child. Clin Orthop Relat Res 348:208–211

    Google Scholar 

  25. Chandan K, Mangat G, Balakrishnan C (2003) RK chinoy, a bhaduri pauciarticular villonodular synovitis in a child. J Indian Rheumatol Assoc 11:14–15

    Google Scholar 

  26. Tavangar SM, Ghafouri M (2005) Multifocal pigmented villonodular synovitis in a child. Singapore Med J 46(4):193–195

    PubMed  CAS  Google Scholar 

  27. Gaubert J, Mazabraut A, Verdié J, Cheneau J (1974) Les synovites villo-nodulaires hemo-pigmentees des grosses articulations. Rev Chir Orthop 60:265–298

    Google Scholar 

  28. Wendt RG, Wolfe F, McQueen D, Murphy P, Solomon H, Housholder M (1986) Polyarticular pigmented villonodular synovitis in children: evidence for a genetic contribution. JRheumatol 13(92):1–926

    Google Scholar 

  29. De Jong B, Castedo SMMJ, Oosterhuis JW, Dam A (1988) Trisomy 7 in a case of angiomyolipoma. Cancer Genet Cytogenet 34:219–222

    Article  PubMed  Google Scholar 

  30. Bridge J, Sanger W, Shaffer B, Neff J (1987) Cytogenetic findings in malignant fibrous histiocytoma. Cancer Genet Cytogenet 29:197–202

    Article  Google Scholar 

  31. Rao A, Vigorita VJ (1984) Pigmented villonodular synovitis (giant cell tumor of the tendons sheaths and synovial membrane). a review of eighty-one cases. J Bone Joint Surg (Am) 66:76–94

    CAS  Google Scholar 

  32. Della Valle GA, Piccaluga F, Potter H, Salvati E, Pusso R (2001) Pigmented villonodular synovitis of the hip: 2 to 23 year followup study. Clin Orthop 388:187–199

    Article  Google Scholar 

  33. Hs S, Kk U, Dj P (1989) Pigmented villonodular synovitis. A retrospective review of affected large joints. Clin Orthop 247:243–255

    Google Scholar 

Download references

Conflict of interest

No funds were received in support of this study. No benefits in any form have been or will be received from a commercial party related directly or indirectly to the subject of this manuscript.

Author information

Authors and Affiliations

  1. Rehabilitation Hospital Iasi, Orthopaedic Surgery, Gr. T. Popa” University of Medicine and Pharmacy, Iasi, Romania

    Paul Botez, Paul Dan Sirbu, Carmen Grierosu, Dan Mihailescu & Liliana Savin

  2. Orthopaedic Traumatology, Emergency Hospital Sf. Spiridon, Iasi, Romania

    Paul Dan Sirbu

  3. Clinique Chirurgicale St Michel, Chirurgie Orthopédique et Traumatologique, Toulon, France

    Marius M. Scarlat

Authors
  1. Paul Botez
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Paul Dan Sirbu
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Carmen Grierosu
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Dan Mihailescu
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Liliana Savin
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Marius M. Scarlat
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Marius M. Scarlat.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Botez, P., Sirbu, P.D., Grierosu, C. et al. Adult multifocal pigmented villonodular synovitis—clinical review. International Orthopaedics (SICOT) 37, 729–733 (2013). https://doi.org/10.1007/s00264-013-1789-5

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00264-013-1789-5

Keywords

Search

Navigation