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Efficacy of aspiration and autogenous bone marrow injection in the treatment of simple bone cysts

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Abstract

Twenty eight patients with simple bone cyst that were treated by aspiration and percutaneous autogenous bone marrow injection were reviewed to evaluate the treatment outcome. There were 18 boys and ten girls. Their mean age was 10.9 ± 2.75 years. Single injection was performed for 16 patients; the rest had double or triple injections. There were no operative complications. The mean follow-up was 34.7 ± 6.87 months. The procedure succeeded in obtaining healing in 23 cysts (82%). Cysts with index of more than five and cortical thickness of less than 1 mm were significantly prone to pathological fractures and had significant poor results after treatment. Our results suggested that autogenous bone marrow injection is a safe and effective treatment method for simple bone cysts, but sometimes repeated injections are necessary. Cyst index and cortical thickness are good indicators for cyst aggressiveness and good predictors for treatment outcome.

Résumé

Vingt huit patients avec un kyste osseux solitaire furent traités par aspiration suivie de l’injection per cutanée de moelle osseuse autologue. Il y avait 18 garçons et 10 filles d’age moyen 10,9 +−2,75 ans. Seize patients ont euune simple injection, les autres 2 ou 3 injections. Il n’y a pas eu de complication. Le suivi moyen était de 34,7 +− 6,87 mois. La cicatrisation fut obtenue pour 23 kystes. Les kystes avec un index de plus de 5 et une épaisseur corticale de moins de 1 mm était plus sujet aux fractures et avaient un moins bon résultat. Ces résultats suggèrent que l’injection de moelle osseuse autologue est une bonne méthode de traitement des kystes osseux, demandant quelquefois des injections répétées. L’index kystique et l’épaisseur corticale sont prédictifs de l’efficacité du traitement.

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References

  1. Arazi M, Senaran H, Memik R, Kapicioglu S (2005) Minimally invasive treatment of simple bone cysts with percutaneous autogenous bone marrow injection. Orthopedics 28(2):108–112

    PubMed  Google Scholar 

  2. Campanacci M, Capanna R, Picci P (1986) Unicameral and aneurysmal bone cysts. Clin Orthop Relat Res 204:25–36

    PubMed  Google Scholar 

  3. Chang CH, Stanton RP, Glutting J (2002) Unicameral bone cysts treated by injection of bone marrow or methylprednisolone. J Bone Joint Surg [Br] 84(3):407–412

    Article  CAS  Google Scholar 

  4. Connolly JF (1998) Clinical use of marrow osteoprogenitor cells to stimulate osteogenesis. Clin Orthop Relat Res 355(Suppl):S257–S266

    Article  PubMed  Google Scholar 

  5. de Sanctis N, Andreacchio A (2006) Elastic stable intramedullary nailing is the best treatment of unicameral bone cysts of the long bones in children? Prospective long-term follow-up study. J Pediatr Orthop 26(4):520–525

    PubMed  Google Scholar 

  6. Delloye C, Docquier PL, Cornu O, Poilvache P, Peters M, Woitrin B, Rombouts JJ, De Nayer P (1998) Simple bone cysts treated with aspiration and a single bone marrow injection. A preliminary report. Int Orthop 22(2):134–138

    Article  PubMed  CAS  Google Scholar 

  7. Docquier PL, Delloye C (2003) Treatment of simple bone cysts with aspiration and a single bone marrow injection. J Pediatr Orthop 23(6):766–773

    PubMed  Google Scholar 

  8. Dormans JP, Sankar WN, Moroz L, Erol B (2005) Percutaneous intramedullary decompression, curettage, and grafting with medical-grade calcium sulfate pellets for unicameral bone cysts in children: a new minimally invasive technique. J Pediatr Orthop 25(6):804–811

    Article  PubMed  Google Scholar 

  9. Kaelin AJ, MacEwen GD (1989) Unicameral bone cysts. Natural history and the risk of fracture. Int Orthop 13(4):275–282

    Article  PubMed  CAS  Google Scholar 

  10. Kanellopoulos AD, Yiannakopoulos CK, Soucacos PN (2005) Percutaneous reaming of simple bone cysts in children followed by injection of demineralized bone matrix and autologous bone marrow. J Pediatr Orthop 25(5):671–675

    Article  PubMed  Google Scholar 

  11. Killian JT, Wilkinson L, White S, Brassard M (1998) Treatment of unicameral bone cyst with demineralized bone matrix. J Pediatr Orthop 18(5):621–624

    Article  PubMed  CAS  Google Scholar 

  12. Lokiec F, Ezra E, Khermosh O, Wientroub S (1996) Simple bone cysts treated by percutaneous autologous marrow grafting. A preliminary report. J Bone Joint Surg [Br] 78(6):934–937

    Article  CAS  Google Scholar 

  13. Lokiec F, Wientroub S (1998) Simple bone cyst: etiology, classification, pathology, and treatment modalities. J Pediatr Orthop B 7(4):262–273

    PubMed  CAS  Google Scholar 

  14. Neer CS, Francis KC, Johnston AD, Kiernan HA Jr (1973) Current concepts on the treatment of solitary unicameral bone cyst. Clin Orthop Relat Res 97:40–51

    Article  PubMed  Google Scholar 

  15. Rougraff BT, Kling TJ (2002) Treatment of active unicameral bone cysts with percutaneous injection of demineralized bone matrix and autogenous bone marrow. J Bone Joint Surg [Am] 84(6):921–929

    Google Scholar 

  16. Scaglietti O, Marchetti PG, Bartolozzi P (1979) The effects of methylprednisolone acetate in the treatment of bone cysts. Results of three years follow-up. J Bone Joint Surg [Br] 61(2):200–204

    Google Scholar 

  17. Tsuchiya H, Abdel-Wanis ME, Uehara K, Tomita K, Takagi Y, Yasutake H (2002) Cannulation of simple bone cysts. J Bone Joint Surg [Br] 84(2):245–248

    Article  CAS  Google Scholar 

  18. Yandow SM, Lundeen GA, Scott SM, Coffin C (1998) Autogenic bone marrow injections as a treatment for simple bone cyst. J Pediatr Orthop 18(5):616–620

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. King Khalid University Hospital, King Saud University, Riyadh, Saudi Arabia

    Mohammed M. Zamzam, Alshahid A. Abak, Khalid A. Bakarman, Fawzi F. Al-Jassir & Marwan M. Zamzami

  2. King Fahd Medical City, Riyadh, Saudi Arabia

    Khalid I. Khoshhal

  3. Department of Orthopedics (49), College of Medicine and King Khalid University Hospital, King Saud University, P.O. Box 7805, Riyadh, 11472, Saudi Arabia

    Mohammed M. Zamzam

Authors
  1. Mohammed M. Zamzam
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  2. Alshahid A. Abak
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  3. Khalid A. Bakarman
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  4. Fawzi F. Al-Jassir
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  5. Khalid I. Khoshhal
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  6. Marwan M. Zamzami
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Correspondence to Mohammed M. Zamzam.

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Study conducted in King Khalid University Hospital, King Saud University, Riyadh, Saudi Arabia.

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Zamzam, M.M., Abak, A.A., Bakarman, K.A. et al. Efficacy of aspiration and autogenous bone marrow injection in the treatment of simple bone cysts. International Orthopaedics (SICOT) 33, 1353–1358 (2009). https://doi.org/10.1007/s00264-008-0619-7

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  • DOI: https://doi.org/10.1007/s00264-008-0619-7

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