Abstract
Sixty New Zealand rabbit models with steroid-induced necrosis of femoral head were exposed to a rotating permanent magnetic field (RPMF) (group A1–2 h/d for one month and group A2–2 h/d for two months), and the changes of femoral head, blood viscosity, serum cholesterol, triglyceride, and pressure within the hip joint cavity were measured and statistically analysed compared to that of control group (B1 and B2) and sham group (C1 and C2). After RPMF treatment, the osteogenesis regeneration of the necrotic femoral head was markedly improved, as was shown by micro-CT. Blood viscosity, serum cholesterol, triglyceride, and pressure in the hip joint cavity were found significantly reduced. RPMF could affect various critical aspects in the course of femoral head necrosis, which will be a promising measure in the prevention and treatment of steroid-induced necrosis of femoral head, especially in the early stage.
Résumé
60 lapins de Nouvelle Zélande présentant une ostéonécrose de la tête fémorale induite par la cortisone ont été exposés à des champs magnétiques rotatoires (groupe A1–2h/d à un mois et groupe A2–2h/d à deux mois). Les modifications de la tête fémorale de la viscosité sanguine du taux de cholestérol et des triglycérides ainsi que les pressions articulaires de la hanche ont été mesurées et analysées statistiquement. Ceci a permis de les comparer à un groupe contrôle (B1 et B2) et à un groupe leurre (C1 et C2). Après traitement par champs magnétiques, la régénération osseuse de la nécrose est améliorée avec une diminution de la viscosité sanguine, du taux de cholestérol et des pressions intra articulaires. Les champs magnétiques peuvent modifier de façon significative l’évolution de la nécrose de la tête fémorale et permettront peut être de prévenir et de traiter les nécroses de la tête fémorale secondaire à un traitement corticoïde surtout à un stade précoce.
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Pan, X., Xiao, D., Zhang, X. et al. Study of rotating permanent magnetic field to treat steroid-induced osteonecrosis of femoral head. International Orthopaedics (SICOT) 33, 617–623 (2009). https://doi.org/10.1007/s00264-007-0506-7
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DOI: https://doi.org/10.1007/s00264-007-0506-7