Abstract
The purpose of this study was to investigate the effects of addition of antibiotics into cement powder on the shear properties of the cement–metal interface. The approach involved adding 800 mg of teicoplanin to 40 g bone cement powder in the t-800 group, 1,600 mg teicoplanin in the t-1,600 group, and no antibiotic in the control group. Industrially prepared bone cement containing 500 mg of gentamicin was used as group g-500. Each group consisted of ten samples. Cement–metal interfaces were produced using metal discs with porous surfaces (1 μm) and templates at the third minute. Shear stability of specimens was measured in a material testing machine. The ANOVA test was used for comparison between the mean shear results of each group. Results showed that mean shear stress to failure values were 12.28 ± 3.35 MPa for the control group, 11.72 ± 3.09 MPa for the t-800 group, 13.25 ± 2.36 MPa for the t-1,600 group and 13.09 ± 2.58 MPa for the g-500 group. No statistically significant differences were found between results of the groups. Results of the study have proven that addition of 1,600 mg of teicoplanin or 500 mg gentamycin in 40 g of bone cement does not decrease the shear strength at the cement–metal interface significantly on the day of application.
Résumé
Arrière plan et propos: quels sont les effets de l’addition d’antibiotiques dans la poudre de ciment sur les contraintes de celui-ci, à l’interface ciment-métal. Méthode: 800 mg de téicoplanine ont été ajoutés à 40 g de poudre de ciment et mis dans le groupe t-800, 1.600 mg de téicoplanine dans le groupe t-1600 et pas d’antibiotique dans un groupe contrôle. Une préparation industrielle du ciment contenant 500 mg de gentamicine a été utilisée dans le groupe g-500. Chaque groupe a rassemblé 10 spécimens. Les contraintes de ces différents spécimens ont été mesurées à l’aide d’une machine. Le test ANOVA a été utilisé pour comparer les différents niveaux de contrainte dans chaque groupe. Résultats: les moyennes des contraintes entraînant une mobilisation a été de 12,28 ± 3,35 MPa pour le groupe contrôle, 11,72 ± 3,09 MPa pour le groupe t-800, 13,25 ± 2,36 MPa pour le groupe t-1600 et enfin 13,09 ± 2,58 MPa pour le groupe g-500. Il n’existe pas de différences significatives entre les deux groupes. En conclusion, on peut indiquer que les résultats de cette étude montrent que l’addition de 1,600 mg de téicoplanine ou de 500 mg de gentamycine dans 40 g de poudre de ciment n’entraîne pas une altération des contraintes au niveau de l’interface ciment-métal de façon significative et le jour de la mise en place de ce ciment.
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Acknowledgments
The authors wish to thank Gamze Kilicoglu, MD for her contributions in preparing the manuscript.
Contribution of authors
Dr. Kilicoglu, Dr. Yazicioglu and Mr. Bozdag designed the study.
Dr. Kilicoglu, Dr. Koyuncu, Dr. Ozden, Mr. Bozdag and Mr. Sunbuloglu gathered the data.
Dr. Kilicoglu and Mr. Bozdag analysed the data.
Dr. Kilicoglu and Mr. Bozdag wrote the initial drafts.
Dr. Ozden and Mr. Bozdag prepared the drawings.
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Kilicoglu, O., Koyuncu, L.O., Ozden, V.E. et al. Effect of antibiotic loading on the shear strength at the stem–cement interface (Shear strength of antibiotic loaded cement). International Orthopaedics (SICO 32, 437–441 (2008). https://doi.org/10.1007/s00264-007-0347-4
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DOI: https://doi.org/10.1007/s00264-007-0347-4