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Effects of rhBMP-2 on cortical strut allograft healing to the femur in revision total hip arthroplasties: an experimental study

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Abstract

We have studied the effects of recombinant human bone morphogenetic protein-2 (rhBMP-2) on cortical strut allograft healing and remodelling in revision hip arthroplasty. Thirty adult New Zealand rabbits underwent bilateral onlay allograft strut procedures to the femur using wires. The left femur (experimental side) received the rhBMP-2 device (1.0-mg rhBMP-2/gelatin composites) interposed between the allograft and host bone, while the right side was grafted with an allograft strut as the control. The femurs and implants were retrieved at 4, 6, and 8 weeks postoperatively. The healing of cortical strut grafts to the femur was enhanced dramatically by the addition of the rhBMP-2 device in radiographic examination, contact radiographic examination, non-decalcification sections, fluorescence tag, and computer-aided image analysis. The remodelling of cortical strut allograft was also accelerated. The new bone formation ratio and radiographic scores of the experimental side were also much higher than the control side at all times. Strut healing with the rhBMP-2 device at 4 weeks postoperatively was superior to the healing in control sides at 8 weeks. Our findings showed that the rhBMP-2 device improved and accelerated the course of cortical strut allograft healing and remodelling with host bone.

Résumé

Nous avons étudié les effets de la BMP recombinante rhBMP-2 sur des allogreffes corticales dans les révisions de prothèses totales. 30 lapins adultes de Nouvelle Zélande ont bénéficié d’une allogreffe bilatérale sur un fémur cerclé avec interposition entre l’allogreffe et l’os receveur au niveau du fémur gauche de rhBMP-2 (1.0 mg rhBMP-2 de gélatines composites), le fémur droit étant greffé avec une allogreffe simple (groupe contrôle). Les fémurs et les implants ont été prélevés à 4, 6, 8 semaines post opératoires. La consolidation par allogreffe corticale a été considérablement améliorée par l’addition de rhBMP-2, tant sur le plan radiographique que sur le plan histologique. La consolidation avec rhBMP-2 à 4 semaines post opératoires est supérieure au groupe contrôle à 8 semaines. Notre expérimentation nous permet de montrer que le rhBMP-2 améliore la consolidation et le remodelage au niveau de l’os receveur des allogreffes corticales.

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  1. Department of Orthopaedics, 2nd Affiliated Hospital, School of Medicine, Zhejiang University, Jie-Fang Road 88#, 310009, Hangzhou, People’s Republic of China

    Li-Dong Wu, Yan Xiong & Hua-Chen Yu

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  1. Li-Dong Wu
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  2. Yan Xiong
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  3. Hua-Chen Yu
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Correspondence to Yan Xiong.

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Wu, LD., Xiong, Y. & Yu, HC. Effects of rhBMP-2 on cortical strut allograft healing to the femur in revision total hip arthroplasties: an experimental study. International Orthopaedics (SICO 31, 605–611 (2007). https://doi.org/10.1007/s00264-006-0235-3

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  • DOI: https://doi.org/10.1007/s00264-006-0235-3

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