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Genetic susceptibility to hip arthroplasty failure—association with the RANK/OPG pathway

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An Erratum to this article was published on 15 November 2007

Abstract

The OPG/RANK/RANKL system has been implicated in the biological cascade of events initiated by particulate wear debris and bacterial infection resulting in periprosthetic bone loss around total hip arthroplasties (THA). Individual responses to such stimuli may be dictated by genetic variation caused by single nucleotide polymorphisms (SNPs). Case control study of the osteoprotegerin and RANK genes for possible association with deep sepsis or aseptic loosening. All patients were Caucasian and had had a cemented Charnley THA and polyethylene acetabular cup. Cases consisted of 91 patients with early aseptic loosening and 71 patients with deep infection. Controls were 150 clinically and radiologically well-fixed THAs. DNA samples were genotyped using Taqman allelic discrimination. The A allele (p<0.001) and genotype A/A (p<0.001) for the OPG-163 SNP were associated with aseptic failure. Additionally, the RANK +575 (C/T SNP) T allele (p=0.004) and T/T genotype (p=0.008) frequencies were associated with aseptic failure. Comparing the septic group with the controls, the frequency of the A allele (p<0.001) and the genotype A/A (p<0.001) for the OPG-163 SNP were statistically significant. Aseptic loosening and deep infection of THA may be under the influence of susceptibility genes. SNP markers may serve as predictors of implant survival.

Résumé

Le système OPG/RANK/RANKL est impliqué dans la cascade des événements initiés par les débris d’usure et l’infection, conduisant à l’ostéolyse périprothètique de la hanche. La réponse individuelle est peut-être génétique, à cause du polymorphisme des nucléotides (SNPs). étude, avec groupe contrôle, des gènes RANK et ostéoprotégérine, et de l’association possible avec l’infection ou le descellement aseptique. Tous les patients étaient caucasiens et avaient eu une prothèse totale de hanche type Charnley avec cupule en polyéthylène. Il y avaient 91 patients avec un descellement aseptique précoce et 71 avec une infection profonde. Le groupe contrôle était constitué de 150 arthroplasties bien fixées cliniquement et radiologiquement. Les échantillons d’ADN étaient génotypés en utilisant la discrimination allèlique Taqman. L’allèle A (p<0,001) et le génotype A/A (p<0,001) pour l’OPG-163SNP était associé avec un échec aseptique. De plus, l’allèle RANK+575 (C/T SNP) T (p=0,004) et le génotype T/T étaient associés a l’échec aseptique. Entre le groupe septique et le groupe contrôle , la fréquence de l’allèle A (p<0,001) et du génotype A/A (p<0,001) pour l’OPG-163SNP était statistiquement différente. Le descellement aseptique et l’infection profonde d’une arthroplastie totale de la hanche peuvent être sous l’influence d’une susceptibilité génétique et les marqueurs spécifiques peuvent servir d’éléments prédictifs de la survie de l’implant.

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Authors and Affiliations

  1. Centre for Hip Surgery, Wrightington Hospital, Hall Lane, Appley Bridge, Wigan, WN6 9EP, UK

    M. H. A. Malik & P. R. Kay

  2. Centre for Integrated Genomic Medical Research, Stopford Building, The University of Manchester, Oxford Road, Manchester, M13 9TP, UK

    M. H. A. Malik, A. Bayat, F. Jury & W. E. R. Ollier

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  1. M. H. A. Malik
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  2. A. Bayat
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  3. F. Jury
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  4. W. E. R. Ollier
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  5. P. R. Kay
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Correspondence to M. H. A. Malik.

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An erratum to this article can be found at http://dx.doi.org/10.1007/s00264-007-0473-z

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Malik, M.H.A., Bayat, A., Jury, F. et al. Genetic susceptibility to hip arthroplasty failure—association with the RANK/OPG pathway. International Orthopaedics (SICO 30, 177–181 (2006). https://doi.org/10.1007/s00264-006-0074-2

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  • DOI: https://doi.org/10.1007/s00264-006-0074-2

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