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Osseointegration in hip prostheses: experimental study in sheep

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Abstract

Sixteen 2- to 3-year-old sheep were submitted to a hemiarthroplasty of the hip joint with a specially designed femoral component. The proximal two thirds of the stem had a circumferential, plasma-sprayed, porous coating with hydroxyapatite. The animals where killed a 15, 30, 60, 90, 120, 180, 200, 270, 360, and 540 days after surgery. Femurs were submitted to plain radiographs, computerised tomography (CT) scan, and dual energy X-ray absorptiometry (DEXA). Cross-sections were obtained at four different levels and studied using scanning electron microscopy. In the coated portion of the stem, apposition of woven immature bone was evident at 15–30 days and mature lamellar bone by 30 days. With time, the gap between the endosteum and the coated surface was filled by bridges of lamellar bone with a marked trabecular orientation. In the distal uncoated portion of the stem, the implant was initially surrounded by fibrous tissue that, with time, transformed into lamellar bone.

Résumé

Seize moutons de 2–3 ans ont subis une hémiarthroplastie de la hanche avec un composant fémoral spécialement conçu. Les 2/3 proximaux de la tige avaient une couche poreuse circonférentielle de plasma vaporisé avec hydroxyapatite. Les animaux ont été sacrifiés aux jours 15, 30, 60, 90, 120, 180, 200, 270, 360 et 540 après chirurgie. Les fémurs ont été soumis à des radiographies ordinaires, une tomodensitométrie, une analyse DEXA. Des sections ont été obtenues à quatre niveaux différents et étudiées en utilisant la microscopie électronique. Dans la portion recouverte de la tige la présence d'os immature était évidente à 15–30 jours et celle d'os lamellaire mature à 30 jours. Avec le temps, l'intervalle entre l'endoste et la surface couverte, a été rempli par des ponts d'os lamellaire d'une orientation trabeculaire marquée. Dans la portion distale, non couverte, de la tige l'implant a été initialement entouré par un tissu fibreux qui avec le temps s'est transformé en os lamellaire.

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Authors and Affiliations

  1. Orthopaedic Department, University of Sassari, Sassari, Italy

    C. Doria

  2. Orthopaedic Department, Catholic University, Rome, Italy

    V. De Santis, G. Falcone, L. Proietti & E. De Santis

  3. Istituto di Clinica Ortopedica, Policlinico Gemelli, Largo A. Gemelli 1, 00168, Rome, Italy

    E. De Santis

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  1. C. Doria
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  2. V. De Santis
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  3. G. Falcone
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  4. L. Proietti
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  5. E. De Santis
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Correspondence to E. De Santis.

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Doria, C., De Santis, V., Falcone, G. et al. Osseointegration in hip prostheses: experimental study in sheep. International Orthopaedics (SICOT) 27, 272–277 (2003). https://doi.org/10.1007/s00264-003-0474-5

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  • DOI: https://doi.org/10.1007/s00264-003-0474-5

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