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Nitric oxide inhibits proliferation but increases life-span of T lymphocytes in tumour-bearing rats

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Abstract

 Nitric oxide (NO) has been shown to inhibit the proliferation of lymphocytes. However, in tumour-bearing rats treated with the immunomodulator OM 163, the regressing nodules were heavily infiltrated by T lymphocytes, although they contained high levels of NO. We show here that NO, while inhibiting the proliferation of lymphocytes, increased their life-span, pointing to the ambivalence of this molecule in the course of tumour growth and regression.

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Authors and Affiliations

  1. Ecole Pratique des Hautes Etudes, Cancer Immunotherapy Research Laboratory, Faculty of Medicine, 7 Bd. Jeanne d’Arc, 21033, Dijon Cedex, France e-mail: jfjeanni@u-bourgogne.fr Tel. and Fax number: +3 33 80 65 39 30, , , , , , FR

    Danièle Reisser, Patricia Lagadec, Nathalie Onier, Dominique Pinard & Jean-François Jeannin

  2. Anatomo-Pathology Laboratory, Centre Georges-François Leclerc, Dijon, France, , , , , , FR

    Laurent Arnould

  3. Experimental Cardiovascular Physiopathology and Pharmacology Laboratory, Faculty of Medicine, Dijon, France, , , , , , FR

    Véronique Maupoil

Authors
  1. Danièle Reisser
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  2. Patricia Lagadec
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  3. Laurent Arnould
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  4. Nathalie Onier
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  5. Véronique Maupoil
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  6. Dominique Pinard
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  7. Jean-François Jeannin
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Additional information

Received: 16 October 1997 / Accepted: 8 January 1998

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Reisser, D., Lagadec, P., Arnould, L. et al. Nitric oxide inhibits proliferation but increases life-span of T lymphocytes in tumour-bearing rats. Cancer Immunol Immunother 46, 160–166 (1998). https://doi.org/10.1007/s002620050474

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  • DOI: https://doi.org/10.1007/s002620050474

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