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Tumor-derived factors modulating dendritic cell function

  • Focussed Research Review
  • Published:
Cancer Immunology, Immunotherapy Aims and scope Submit manuscript

Abstract

Dendritic cells (DC) play unique and diverse roles in the tumor occurrence, development, progression and response to therapy. First of all, DC can actively uptake tumor-associated antigens, process them and present antigenic peptides to T cells inducing and maintaining tumor-specific T cell responses. DC interaction with different immune effector cells may also support innate antitumor immunity, as well as humoral responses also known to inhibit tumor development in certain cases. On the other hand, DC are recruited to the tumor site by specific tumor-derived and stroma-derived factors, which may also impair DC maturation, differentiation and function, thus resulting in the deficient formation of antitumor immune response or development of DC-mediated tolerance and immune suppression. Identification of DC-stimulating and DC-suppressing/polarizing factors in the tumor environment and the mechanism of DC modulation are important for designing effective DC-based vaccines and for recovery of immunodeficient resident DC responsible for maintenance of clinically relevant antitumor immunity in patients with cancer. DC-targeting tumor-derived factors and their effects on resident and administered DC in the tumor milieu are described and discussed in this review.

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Abbreviations

ACVR1:

Activin receptor 1

BMPR:

Bone morphogenetic protein receptor

COX:

Cyclooxygenases

CSF-1:

Colony-stimulating factor 1

CSIF:

Cytokine synthesis inhibitory factor

CTL:

Cytotoxic T cell(s)

DAMP:

Damage-associated molecular pattern

DC:

Dendritic cell(s)

DR6:

Death receptor 6

ER:

Endoplasmic reticulum

FABP4:

Fatty acid-binding protein

GDF-15:

Growth differentiation factor-15

HCG:

Human chorionic gonadotropin

HMGB1:

Chromatin-binding protein high-mobility group box 1

HSP:

Heat-shock protein(s)

IDO:

Indoleamine-2, 3-dioxygenase

IL-10:

Interleukin-10

LPL:

Lipoprotein lipase

M-CSF:

Macrophage colony-stimulating factor

MIC-1:

Macrophage inhibitory cytokine-1

MMP:

Matrix metalloproteinase

MUC1:

Mucin 1

NMDAR:

N-methyl-d-aspartate receptor

PD-L1:

Programmed death ligand 1

PSA:

Prostate-specific antigen

RAGE:

Receptor for advanced glycation end product

regDC:

Regulatory dendritic cell(s)

ROS:

Reactive oxygen species

SDF-1:

Stromal cell-derived factor-1

STAT3:

Signal transducers and activators of transcription 3

TGF-β:

Transforming growth factor beta

TGFBR:

TGF-β receptor

TIM-3:

T cell immunoglobulin domain and mucin domain-3

TLR:

Toll-like receptor

Treg:

Regulatory T cell(s)

TREM1:

Triggering receptor expressed on myeloid cell-1

UPR:

Unfolded protein response

VEGF:

Vascular endothelial growth factor

XBP1:

X-box-binding protein 1

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Acknowledgments

This work was supported in part by the National Institutes of Health (NIH), Grant RO1 CA154369 (to Shurin).

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Authors and Affiliations

  1. Department of Pathology, University of Pittsburgh Medical Center, Scaife Hall S735, 3550 Terrace Street, Pittsburgh, PA, 15261, USA

    Jinbao Zong, Anton A. Keskinov, Galina V. Shurin & Michael R. Shurin

  2. Department of Immunology, University of Pittsburgh Medical Center, Pittsburgh, PA, USA

    Michael R. Shurin

  3. Department of Clinical Laboratory, The Affiliated Hospital of Qingdao University, Qingdao City, China

    Jinbao Zong

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  1. Jinbao Zong
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  2. Anton A. Keskinov
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  3. Galina V. Shurin
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Correspondence to Michael R. Shurin.

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This paper is a Focussed Research Review based on a presentation given at the Fourth International Conference on Cancer Immunotherapy and Immunomonitoring (CITIM 2015), held in Ljubljana, Slovenia, 27th–30th April 2015. It is part of a series of Focussed Research Reviews and meeting report in Cancer Immunology, Immunotherapy.

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Zong, J., Keskinov, A.A., Shurin, G.V. et al. Tumor-derived factors modulating dendritic cell function. Cancer Immunol Immunother 65, 821–833 (2016). https://doi.org/10.1007/s00262-016-1820-y

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