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Polymorphisms of pro-inflammatory genes and prostate cancer risk: a pharmacogenomic approach

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Abstract

In this paper, we consider the role of the genetics of inflammation in the pathophysiology of prostate cancer (PCa). This paper is not an extensive review of the literature, rather it is an expert opinion based on data from authors’ laboratories on age-related diseases and inflammation. The aim is the detection of a risk profile that potentially allows both the early identification of individuals at risk for disease and the possible discovery of potential targets for medication. In fact, a major goal of clinical research is to improve early detection of age-related diseases, cancer included, by developing tools to move diagnosis backward in disease temporal course, i.e., before the clinical manifestation of the malady, where treatment might play a decisive role in preventing or significantly retarding the manifestation of the disease. The better understanding of the function and the regulation of inflammatory pathway in PCa may help to know the mechanisms of its formation and progression, as well as to identify new targets for the refinement of new treatment such as the pharmacogenomics approach.

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Acknowledgments

This work was supported by the Italian Ministry of Health grant (Molecular mechanisms of stem cancer cell survival control) to G. Carruba and C. Caruso and by Ministry of Education, University and Research (ex60%)grant to G. Candore and C. Caruso. The ‘‘Immunosenesence Research Group’’ coordinated by Prof. C. Caruso in association with ARNAS Experimental Oncology was amplified thanks to a joint contract.

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Authors and Affiliations

  1. Gruppo di Studio sull’Immunosenescenza, Dipartimento di Biopatologia e Metodologie Biomediche, Università di Palermo, Palermo, Italy

    Calogero Caruso, Carmela Rita Balistreri, Giuseppina Candore, Giuseppe Carruba, Giuseppina Colonna-Romano, Danilo Di Bona, Giusi Irma Forte, Domenico Lio, Florinda Listì, Letizia Scola & Sonya Vasto

  2. Medicina Trasfusionale ed Immunoematologia, Ospedale Universitario, Palermo, Italy

    Calogero Caruso, Danilo Di Bona, Letizia Scola & Sonya Vasto

  3. Oncologia Sperimentale, Dipartimento di Oncologia, ARNAS-Ospedale Civico, Palermo, Italy

    Giuseppe Carruba

  4. Istituto di Biomedicina ed Immunologia Molecolare, Consiglio Nazionale delle Ricerche, Palermo, Italy

    Danilo Di Bona

  5. Cattedra di Patologia Clinica, Dipartimento di Biopatologia e Metodologie Biomediche, Università di Palermo, Palermo, Italy

    Giusi Irma Forte, Domenico Lio & Letizia Scola

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  1. Calogero Caruso
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Correspondence to Calogero Caruso.

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This article is part of the Symposium in Writing on “Impact of Ageing on Cancer Immunity and Immunotherapy”.

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Caruso, C., Balistreri, C.R., Candore, G. et al. Polymorphisms of pro-inflammatory genes and prostate cancer risk: a pharmacogenomic approach. Cancer Immunol Immunother 58, 1919–1933 (2009). https://doi.org/10.1007/s00262-009-0658-y

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