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Targeted immunotherapy in acute myeloblastic leukemia: from animals to humans

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Abstract

Immunity against acute myeloid leukemia (AML) is demonstrated in humans by the graft-versus-leukemia effect in allogeneic hematopoietic stem cell transplantation. Specific leukemic antigens have progressively been discovered and circulating specific T lymphocytes against Wilms tumor antigen, proteinase peptide or fusion-proteins produced from aberrant oncogenic chromosomal translocations have been detected in leukemic patients. However, due to the fact that leukemic blasts develop various escape mechanisms, antileukemic specific immunity is not able to control leukemic cell proliferation. The aim of immunotherapy is to overcome tolerance and boost immunity to elicit an efficient immune response against leukemia. We review different immunotherapy strategies tested in preclinical animal models of AML and the human trials that spurred from encouraging results obtained in animal models, demonstrate the feasibility of immunotherapy in AML patients.

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Author notes

  1. Rose-Ann Padua

    Present address: INSERM U718, Institut Universitaire d’Hématologie, Hôpital Saint-Louis, Paris, France

Authors and Affiliations

  1. LBCH INSERM U718, Hôpital Saint Louis APHP, Institut Universitaire d’Hématologie, 1 Avenue Claude Vellefaux, 75010, Paris, France

    Marie Robin, Marie-Hélène Schlageter, Christine Chomienne & Rose-Ann Padua

  2. Service de Greffe de Moelle, Hôpital Saint Louis, Paris, France

    Marie Robin

  3. Service de Médecine Nucléaire, Hôpital Saint-Louis, Paris, France

    Marie-Hélène Schlageter & Christine Chomienne

  4. Department of Haematological Medicine, King’s College London, United Kingdom

    Rose-Ann Padua

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Robin, M., Schlageter, MH., Chomienne, C. et al. Targeted immunotherapy in acute myeloblastic leukemia: from animals to humans. Cancer Immunol Immunother 54, 933–943 (2005). https://doi.org/10.1007/s00262-005-0678-1

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  • DOI: https://doi.org/10.1007/s00262-005-0678-1

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