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Effective immunotherapy against cancer

A question of overcoming immune suppression and immune escape?

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Cancer Immunology, Immunotherapy Aims and scope Submit manuscript

Abstract

During the last decade, the breakthroughs in understanding of the molecular mechanisms responsible for immune activation and the advent of recombinant DNA technologies have changed the view on immunotherapy from “a dream scenario” to becoming a clinical reality. It is now clear that both cellular immunity comprising T and NK cells, as well as strategies based on antibodies, can provide strong antitumoral effects, and evidence is emerging that these strategies may also cure patients with previously incurable cancers. However, there are still a number of issues that remain unresolved. Progress in immunotherapy against cancer requires a combination of new, improved clinical protocols and strategies for overcoming mechanisms of immune escape and tumor-induced immune suppression. This review discusses some of the salient issues that still need to be resolved, focusing on the role of oxidative stress and the use of antioxidants to alleviate the immune hyporesponsiveness induced by reactive oxygen species (ROS).

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Abbreviations

HLA:

Human leukocyte antigen

KIR:

Killer cell immunoglobulin-like receptor

NKR:

Natural killer cell receptor

ROS:

Reactive oxygen species

TAA:

Tumor-associated antigen

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Acknowledgements

This work was supported by grants from the Swedish Foundation for Strategic Research, the Swedish Society for Medical Research and the Swedish Cancer Society.

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  1. Center for Infectious Medicine (CIM), F59, Department of Medicine, Karolinska Institutet, Karolinska University Hospital Huddinge, S-14186, Stockholm, Sweden

    Karl-Johan Malmberg

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Correspondence to Karl-Johan Malmberg.

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This work is part of the Symposium in Writing “Tumor escape from the immune response,” published in vol 53.

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Malmberg, KJ. Effective immunotherapy against cancer. Cancer Immunol Immunother 53, 879–892 (2004). https://doi.org/10.1007/s00262-004-0577-x

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