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Exosome-based immunotherapy

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Abstract

Exosomes are small membrane vesicles originating from late endosomes and secreted by hematopoietic and epithelial cells in culture. Exosome proteic and lipid composition is unique and might shed some light into exosome biogenesis and function. Exosomes secreted from professional antigen-presenting cells (i.e., B lymphocytes and dendritic cells) are enriched in MHC class I and II complexes, costimulatory molecules, and hsp70–90 chaperones, and have therefore been more extensively studied for their immunomodulatory capacities in vitro and in vivo. This review will present the main biological features pertaining to tumor or DC-derived exosomes, will emphasize their immunostimulatory function, and will discuss their implementation in cancer immunotherapy.

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Fig. 1A, B

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Abbreviations

APC:

antigen-presenting cell

ASI:

active specific immunotherapy

CTL:

cytotoxic T lymphocyte

DC:

dendritic cell

FDC:

follicular dendritic cell

MD-DC:

monocyte-derived dendritic cell

GMP:

good manufacturing procedure

HLA:

human leukocyte antigen

HSP:

heat shock protein

MHC:

major histocompatibility complex

MVB:

multivesicular body

ExAs:

ascitis-derived exosomes

DEX:

DC-derived exosome

TEX:

tumor cell–derived exosome

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Authors and Affiliations

  1. ERIT-M 02-08 INSERM, Department of Clinical Biology, Institut Gustave Roussy (IGR), 39 rue Camille Desmoulins, 94805, Villejuif, France

    Nathalie Chaput, Julien Taïeb, Noël E. C. Schartz, Fabrice André, Eric Angevin & Laurence Zitvogel

  2. Department of Hepatology and Gastroenterology, Pitié Salpétrière Hospital, Paris, France

    Julien Taïeb

  3. Department of Dermatology, Saint Louis Hospital, Paris, France

    Noël E. C. Schartz

  4. Department of Medical Oncology, Institut Gustave Roussy (IGR), Villejuif, France

    Fabrice André

Authors
  1. Nathalie Chaput
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  2. Julien Taïeb
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  3. Noël E. C. Schartz
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  4. Fabrice André
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  5. Eric Angevin
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  6. Laurence Zitvogel
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Corresponding author

Correspondence to Laurence Zitvogel.

Additional information

This work was presented at the first Cancer Immunology and Immunotherapy Summer School, 8–13 September 2003, Ionian Village, Bartholomeio, Peloponnese, Greece.

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Chaput, N., Taïeb, J., Schartz, N.E.C. et al. Exosome-based immunotherapy. Cancer Immunol Immunother 53, 234–239 (2004). https://doi.org/10.1007/s00262-003-0472-x

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  • DOI: https://doi.org/10.1007/s00262-003-0472-x

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