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Quantification of fat and skeletal muscle tissue at abdominal computed tomography: associations between single-slice measurements and total compartment volumes

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Abstract

Purpose

Body composition is of great prognostic value in several severe diseases, including different types of cancer as well as cardiometabolic disorders. We aimed to investigate the correlations of skeletal muscle mass and abdominal adipose tissue compartments between volumetric and single-slice measurements to study the usefulness of several anatomical landmarks for estimation of total compartment volumes using abdominal CT-scans.

Methods

In this retrospective study volumetric quantifications of paraspinal skeletal muscles (SM) and adipose tissue compartments (visceral adipose tissue, VAT; subcutaneous adipose tissue, SAT) were performed in 50 consecutive patients (26 male; mean age, 63 ± 15 years) who underwent abdominal multislice-CT for diagnostic purposes using an in-house software. Associations between total volumes of SM, VAT, and SAT with single-slice measurements at eight predefined anatomical landmarks (median intervertebral disk spaces T12/L1 to L5/S1; level of the umbilicus (U); level of the radix of the superior mesenteric artery (SMA)) were studied using correlation coefficients.

Results

Statistical analysis revealed a strong association between single-slice measurements of adipose tissue compartments with total VAT and SAT volume (VAT: all r > 0.89, P < 0.001; SAT: all r > 0.95, P < 0.001). The strongest associations with total SM volume were found for single-slice measurements obtained at L3/4 (r = 0.94, P < 0.001) and were further improved by normalization to height (r = 0.98, P < 0.001).

Conclusions

Single-slice measurements of SM, VAT, and SAT at several anatomical landmarks are strongly associated with total compartment volumes and therefore allow for easy and simultaneous assessment of skeletal muscle mass and adipose tissue compartment volumes.

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Abbreviations

BMI:

Body mass index

CT:

Computed tomography

ROI:

Region of interest

SAT:

Subcutaneous adipose tissue

SMA:

Superior mesenteric artery

SM:

Paraspinal skeletal muscle mass

SMVH:

Paraspinal skeletal muscle mass normalized to volume of interest height

VAT:

Visceral adipose tissue

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Authors and Affiliations

  1. Department of Radiology, University of Bonn, Sigmund-Freud-Str. 25, 53127, Bonn, Germany

    Anton Faron, Julian A. Luetkens, Frederic C. Schmeel, Daniel L.R. Kuetting, Daniel Thomas & Alois M. Sprinkart

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  1. Anton Faron
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  2. Julian A. Luetkens
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  3. Frederic C. Schmeel
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  4. Daniel L.R. Kuetting
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Correspondence to Anton Faron.

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Faron, A., Luetkens, J.A., Schmeel, F.C. et al. Quantification of fat and skeletal muscle tissue at abdominal computed tomography: associations between single-slice measurements and total compartment volumes. Abdom Radiol 44, 1907–1916 (2019). https://doi.org/10.1007/s00261-019-01912-9

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