Skip to main content

Advertisement

Log in

A retrospective analysis of complication and adequacy rates of ultrasound-guided native and transplant non-focal renal biopsies

  • Published:
Abdominal Radiology Aims and scope Submit manuscript

Abstract

Purpose

To assess non-focal ultrasound (US)-guided renal biopsy complication and adequacy rates at our institution.

Methods

A retrospective analysis of 1067 non-focal renal biopsy cases between 2012 and 2015. Information collected including type of US-guided procedure (US-localized by nephrology vs. real-time US-guided by radiology), sample adequacy, complications, blood work, and histologic data.

Results

602 biopsies were performed by radiology (56.4%) and 465 (43.6%) by nephrology. The overall adequacy rate was 96.1%, with an US-localized rate of 95.7% and real-time US-guided rate of 96.3% (p = 0.58). A lower adequacy rate was noted for 1 biopsy core but there were no differences between 2 and 6 cores (p = 0.001). A lower adequacy rate was found for transplant biopsies vs. native biopsies (p = 0.03). Complication rates were as follows—minor 5.9%, major 4.3%, and life-threatening 0.8%. There were no differences in complication rates between the US-localized and real-time US-guided techniques (p = 0.63). Complications were more likely in patients with a lower hemoglobin, higher serum creatinine, and lower albumin (p < 0.05). No differences were found between the number of cores performed and the complication rates. The complication rate was similar between transplant biopsies vs. native biopsies (p = 0.2). The adequacy rate was lower in trainees (p = 0.01) than experienced radiologists.

Conclusions

No significant differences were found between US-localized vs. real-time US-guided techniques. A lower adequacy rate was found for trainee radiologists and for transplant biopsies. A lower adequacy rate was also observed when only 1 biopsy pass was performed.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  1. Visconti L, Cernaro V, Ricciardi CA, et al. (2016) Renal biopsy: still a landmark for the nephrologist. World J Nephrol 5:321–327

    Article  PubMed  PubMed Central  Google Scholar 

  2. Ali H, Murtaza A, Anderton J, Ahmed A (2015) Post renal biopsy complication rate and diagnostic yield comparing hands free (ultrasound-assisted) and ultrasound-guided biopsy techniques of renal allografts and native kidneys. Springerplus 4:491

    Article  PubMed  PubMed Central  Google Scholar 

  3. Maya ID, Maddela P, Barker J, Allon M (2007) Percutaneous renal biopsy: comparison of blind and real-time ultrasound-guided technique. Semin Dial 20:355–358

    Article  PubMed  Google Scholar 

  4. Roccatello D, Sciascia S, Rossi D, et al. (2017) Outpatient percutaneous native renal biopsy: safety profile in a large monocentric cohort. BMJ Open 7:e015243

    Article  PubMed  PubMed Central  Google Scholar 

  5. Chung S, Koh ES, Kim SJ, et al. (2014) Safety and tissue yield for percutaneous native kidney biopsy according to practitioner and ultrasound technique. BMC Nephrol 15:96

    Article  PubMed  PubMed Central  Google Scholar 

  6. Sekulic M, Crary GS (2017) Kidney biopsy yield: an examination of influencing factors. Am J Surg Pathol 41:961–972

    Article  PubMed  Google Scholar 

  7. Gupta RK, Balogun RA (2005) Native renal biopsies: complications and glomerular yield between radiologists and nephrologists. J Nephrol 18:553–558

    PubMed  Google Scholar 

  8. Chunduri S, Whittier WL, Korbet SM (2015) Adequacy and complication rates with 14- vs. 16-gauge automated needles in percutaneous renal biopsy of native kidneys. Semin Dial 28:E11–14

    Article  PubMed  Google Scholar 

  9. Prasad N, Kumar S, Manjunath R, et al. (2015) Real-time ultrasound-guided percutaneous renal biopsy with needle guide by nephrologists decreases post-biopsy complications. Clin Kidney J 8:151–156

    Article  PubMed  PubMed Central  Google Scholar 

  10. Xu DM, Chen M, Zhou FD, Zhao MH (2017) Risk factors for severe bleeding complications in percutaneous renal biopsy. Am J Med Sci 353:230–235

    Article  PubMed  Google Scholar 

  11. Kriegshauser JS, Patel MD, Young SW, et al. (2016) Factors contributing to the success of ultrasound-guided native renal biopsy. J Ultrasound Med 35:381–387

    Article  PubMed  Google Scholar 

  12. Patel MD, Phillips CJ, Young SW, et al. (2010) US-guided renal transplant biopsy: efficacy of a cortical tangential approach. Radiology 256:290–296

    Article  PubMed  Google Scholar 

  13. Song JH, Cronan JJ (1998) Percutaneous biopsy in diffuse renal disease: comparison of 18- and 14-gauge automated biopsy devices. J Vasc Interv Radiol 9:651–655

    Article  PubMed  CAS  Google Scholar 

  14. Pullman JM, Ferrario F, Nast CC (2007) Actual practices in nephropathology: a survey and comparison with best practices. Adv Anat Pathol 14:132–140

    Article  PubMed  Google Scholar 

  15. Korbet SM, Volpini KC, Whittier WL (2014) Percutaneous renal biopsy of native kidneys: a single-center experience of 1055 biopsies. Am J Nephrol 39:153–162

    Article  PubMed  Google Scholar 

  16. Tondel C, Vikse BE, Bostad L, Svarstad E (2012) Safety and complications of percutaneous kidney biopsies in 715 children and 8573 adults in Norway 1988–2010. Clin J Am Soc Nephrol 7:1591–1597

    Article  PubMed  PubMed Central  Google Scholar 

  17. Torres Munoz A, Valdez-Ortiz R, Gonzalez-Parra C, et al. (2011) Percutaneous renal biopsy of native kidneys: efficiency, safety and risk factors associated with major complications. Arch Med Sci 7:823–831

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  18. Winkelmayer WC, Levin R, Avorn J (2003) Chronic kidney disease as a risk factor for bleeding complications after coronary artery bypass surgery. Am J Kidney Dis 41:84–89

    Article  PubMed  Google Scholar 

  19. Preuss S, Kuechle C, Wagenpfeil S, et al. (2017) Retrospective analysis of ultrasound-detected bleeding complications after ultrasound-guided transcutaneous kidney biopsies. Ultrasound Med Biol 43:153–162

    Article  PubMed  Google Scholar 

  20. Preda A, Van Dijk LC, Van Oostaijen JA, Pattynama PM (2003) Complication rate and diagnostic yield of 515 consecutive ultrasound-guided biopsies of renal allografts and native kidneys using a 14-gauge Biopty gun. Eur Radiol 13:527–530

    PubMed  Google Scholar 

  21. Gilani SM, Ockner D, Qu H (2013) Role of on-site microscopic evaluation of kidney biopsy for adequacy and allocation of glomeruli: comparison of renal biopsies with and without on-site microscopic evaluation. Pathologica 105:342–345

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Craig Ferguson.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Ferguson, C., Winters, S., Jackson, S. et al. A retrospective analysis of complication and adequacy rates of ultrasound-guided native and transplant non-focal renal biopsies. Abdom Radiol 43, 2183–2189 (2018). https://doi.org/10.1007/s00261-017-1405-z

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00261-017-1405-z

Keywords

Navigation