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Pancreatic adenocarcinoma: dynamic 64-slice helical CT with perfusion imaging

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Abstract

Background

Perfusion CT is able to outline blood perfusion changes in a tissue. Thus, in lesions of the tissues of the pancreas, this offers to increase the accuracy of CT diagnosis. In this study, our aim was to explore the perfusion characteristics of normal pancreas and pancreatic adenocarcinoma.

Methods

Dynamic 64-slice helical CT was conducted in 36 patients with non-pancreatic disease and in 40 patients with histopathologically proven pancreatic adenocarcinoma. Perfusion parameters including blood flow (BF), blood volume (BV), and permeability surface area product (PS) were recorded.

Results

There was no significant difference noted between the distribution of BF, BV, and PS values in different regions of the pancreas, namely the head, neck, body, and tail (P > 0.05). The BF, BV, and PS of normal pancreas were recorded as 135.24 ± 48.36 ml min−1 100 g−1, 200.55 ± 54.96 ml 100 g−1, and 49.75 ± 24.27 ml min−1 100 g−1, respectively. BF, BV, and PS values of the tumor tissue of pancreatic adenocarcinoma decreased significantly compared to normal pancreas (P < 0.05).

Conclusions

Normal pancreas appears homogenous on perfusion CT. A significant decrease of BF, BV, and PS was observed in pancreatic adenocarcinoma. Dynamic 64-slice helical CT with perfusion imaging should be considered a potential modality to increase the accuracy of CT diagnosis for pancreatic adenocarcinoma.

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Acknowledgments

This study was supported by the Shanghai Committee of Science and Technology, China (Grant No. 054119504, 004119009).

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Authors and Affiliations

  1. Department of General Surgery, Pancreatic Disease Institution, Huashan Hospital, Fudan University, Shanghai, 200040, China

    Jin Xu, Sijie Hao, Maskay Ashish, Chen Jin, Deliang Fu & Quanxing Ni

  2. Department of Radiology, Pancreatic Disease Institution, Huashan Hospital, Fudan University, Shanghai, 200040, China

    Zonghui Liang & Li Zhu

Authors
  1. Jin Xu
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  2. Zonghui Liang
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  3. Sijie Hao
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  4. Li Zhu
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  5. Maskay Ashish
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  6. Chen Jin
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  7. Deliang Fu
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  8. Quanxing Ni
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Corresponding author

Correspondence to Chen Jin.

Additional information

Jin Xu and Zonghui Liang contributed equally to this work.

Jin Xu, Zonghui Liang, and Chen Jin were involved in conception and design of the study; Sijie Hao, Li Zhu, and Maskay Ashish were involved in the collection and assembly of data; Jin Xu, Zonghui Liang, Chen Jin, Deliang Fu, and Quanxing Ni were involved in data analysis and interpretation; Jin Xu, Sijie Hao, Maskay Ashish, and Chen Jin were involved in manuscript writing. All authors reviewed the manuscript and gave their approval.

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Xu, J., Liang, Z., Hao, S. et al. Pancreatic adenocarcinoma: dynamic 64-slice helical CT with perfusion imaging. Abdom Imaging 34, 759–766 (2009). https://doi.org/10.1007/s00261-009-9564-1

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  • DOI: https://doi.org/10.1007/s00261-009-9564-1

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