Abstract
The purpose of this study was to retrospectively assess the diagnostic performance of diffusion-weighted imaging (DWI) and dynamic contrast-enhanced imaging (DCEI) at 3T in predicting locally recurrent prostate cancer after radiation therapy. Twenty-four patients with a rising prostate-specific antigen level after treatment with radiation therapy underwent prostate MR imaging at 3T, followed by transrectal ultrasound-guided biopsy. MRI findings and biopsy results were correlated in six prostate sectors of both peripheral zones. Two radiologists in consensus reviewed the MR images and rated the likelihood of recurrent cancer on a 5-point scale. Out of the 144 prostate sectors, 37 (26%) sectors were positive for cancer in ten patients. For predicting locally recurrent cancer, the sensitivity and specificity of DWI, DCEI, and combined DCEI and DWI were higher than those for T2-weighted imaging (T2WI). The accuracy of DWI, DCEI and combined DCEI and DWI was greater than that of T2WI. A significantly greater Az was determined for combined DCEI and DWI (Az = 0.863, P < 0.05) as compared with T2WI, DCEI, and DWI. For predicting locally recurrent prostate cancer after radiation therapy, our preliminary results suggest that the use of either DWI or DCEI is superior to the use of T2WI.
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Shipley WU, Thames HD, Sandler HM, et al. (1999) Radiation therapy for clinically localized prostate cancer: a multi-institutional pooled analysis. Jama 281:1598–1604
Lee WR, Moughan J, Owen JB, Zelefsky MJ (2003) The 1999 patterns of care study of radiotherapy in localized prostate carcinoma: a comprehensive survey of prostate brachytherapy in the United States. Cancer 98:1987–1994
Grado GL, Collins JM, Kriegshauser JS, et al. (1999) Salvage brachytherapy for localized prostate cancer after radiotherapy failure. Urology 53:2–10
Stephenson AJ, Scardino PT, Bianco FJ, Jr, Eastham JA (2004) Salvage therapy for locally recurrent prostate cancer after external beam radiotherapy. Curr Treat Options Oncol 5:357–365
Shekarriz B, Upadhyay J, Pontes JE (2001) Salvage radical prostatectomy. Urol Clin North Am 28:545–553
Boccon-Gibod L, Djavan WB, Hammerer P, et al. (2004) Management of prostate-specific antigen relapse in prostate cancer: a European Consensus. Int J Clin Pract 58:382–390
Coakley FV, Hricak H, Wefer AE, et al. (2001) Brachytherapy for prostate cancer: endorectal MR imaging of local treatment-related changes. Radiology 219:817–821
Rouviere O, Valette O, Grivolat S, et al. (2004) Recurrent prostate cancer after external beam radiotherapy: value of contrast-enhanced dynamic MRI in localizing intraprostatic tumor—correlation with biopsy findings. Urology 63:922–927
Pucar D, Shukla-Dave A, Hricak H, et al. (2005) Prostate cancer: correlation of MR imaging and MR spectroscopy with pathologic findings after radiation therapy-initial experience. Radiology 236:545–553
Heijmink SW, Scheenen TW, Futterer JJ, et al. (2007) Prostate and lymph node proton magnetic resonance (MR) spectroscopic imaging with external array coils at 3 T to detect recurrent prostate cancer after radiation therapy. Invest Radiol 42:420–427
Sala E, Akin O, Moskowitz CS, et al. (2006) Endorectal MR imaging in the evaluation of seminal vesicle invasion: diagnostic accuracy and multivariate feature analysis. Radiology 238:929–937
Pickett B, Kurhanewicz J, Coakley F, et al. (2004) Use of MRI and spectroscopy in evaluation of external beam radiotherapy for prostate cancer. Int J Radiat Oncol Biol Phys 60:1047–1055
Futterer JJ, Scheenen TW, Heijmink SW, et al. (2007) Standardized threshold approach using three-dimensional proton magnetic resonance spectroscopic imaging in prostate cancer localization of the entire prostate. Invest Radiol 42:116–122
Kim CK, Park BK (2008) Update of prostate magnetic resonance imaging at 3 T. J Comput Assist Tomogr 32:163–172
Tanenbaum LN (2006) Clinical 3T MR imaging: mastering the challenges. Magn Reson Imaging Clin N Am 14:1–15
Manenti G, Carlani M, Mancino S, et al. (2007) Diffusion tensor magnetic resonance imaging of prostate cancer. Invest Radiol 42:412–419
Kim CK, Park BK, Lee HM, Kwon GY (2007) Value of diffusion-weighted imaging for the prediction of prostate cancer location at 3T using a phased-array coil: preliminary results. Invest Radiol 42:842–847
American Society for Therapeutic Radiology and Oncology Consensus Panel (1997) Consensus statement: guidelines for PSA following radiation therapy. Int J Radiat Oncol Biol Phys 37:1035–1041
Huisman HJ, Engelbrecht MR, Barentsz JO (2001) Accurate estimation of pharmacokinetic contrast-enhanced dynamic MRI parameters of the prostate. J Magn Reson Imaging 13:607–614
Kim CK, Park BK, Kim B (2006) Localization of prostate cancer using 3T MRI: comparison of T2-weighted and dynamic contrast-enhanced imaging. J Comput Assist Tomogr 30:7–11
Futterer JJ, Heijmink SW, Scheenen TW, et al. (2006) Prostate cancer localization with dynamic contrast-enhanced MR imaging and proton MR spectroscopic imaging. Radiology 241:449–458
Schaefer PW, Grant PE, Gonzalez RG (2000) Diffusion-weighted MR imaging of the brain. Radiology 217:331–345
Lichy MP, Aschoff P, Plathow C, et al. (2007) Tumor Detection by Diffusion-Weighted MRI and ADC-Mapping-Initial Clinical Experiences in Comparison to PET-CT. Invest Radiol 42:605–613
Schaefer PW, Ozsunar Y, He J, et al. (2003) Assessing tissue viability with MR diffusion and perfusion imaging. AJNR Am J Neuroradiol 24:436–443
Abdel Razek AA, Kandeel AY, Soliman N, et al. (2007) Role of diffusion-weighted echo-planar MR imaging in differentiation of residual or recurrent head and neck tumors and posttreatment changes. AJNR Am J Neuroradiol 28:1146–1152
Hein PA, Eskey CJ, Dunn JF, Hug EB (2004) Diffusion-weighted imaging in the follow-up of treated high-grade gliomas: tumor recurrence versus radiation injury. AJNR Am J Neuroradiol 25:201–209
Baur A, Huber A, Arbogast S, et al. (2001) Diffusion-weighted imaging of tumor recurrences and posttherapeutical soft-tissue changes in humans. Eur Radiol 11:828–833
Takayama Y, Kishimoto R, Hanaoka S, et al. (2008) ADC value and diffusion tensor imaging of prostate cancer: changes in carbon-ion radiotherapy. J Magn Reson Imaging 27:1331–1335
Crook J, Malone S, Perry G, et al. (2000) Postradiotherapy prostate biopsies: what do they really mean? Results for 498 patients. Int J Radiat Oncol Biol Phys 48:355–367
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Kim, C.K., Park, B.K., Park, W. et al. Prostate MR imaging at 3T using a phased-arrayed coil in predicting locally recurrent prostate cancer after radiation therapy: preliminary experience. Abdom Imaging 35, 246–252 (2010). https://doi.org/10.1007/s00261-008-9495-2
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DOI: https://doi.org/10.1007/s00261-008-9495-2