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Examining the immune response in sentinel lymph nodes of mice and men

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Abstract.

Recently, it was recognized that an immune response develops along one of two major pathways. One leads to a destructive immune response (type 1), while the alternative leads to a nondestructive immune response (type 2). Our studies in animal models suggest that therapeutic vaccines induce a tumor-specific type 1 immune response while ineffective vaccines induce a type 2 response. These results have led us to examine the immune response in sentinel lymph nodes draining tumor vaccines of patients entered onto clinical trials for melanoma, breast and renal cell cancer.

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Authors and Affiliations

  1. Robert W. Franz Cancer Research Center, Earle A. Chiles Research Institute, Providence Poartland Medical Center, Portland, OR 97213, USA, , , , , , CL

    Y. Chu, H.-M. Hu, H. Winter, W. J. Wood, T. Doran, D. Lashley, J. Bashey, J. Schuster, J. Wood, A. D. Weinberg, J. W. Smith II, W. J. Urba & B. A. Fox

  2. Department of Surgery, Oregon Health Sciences University, Portland, OR 97201, USA, , , , , , US

    B. A. Lowe & J. T. Vetto

  3. Division of Cellular and Gene Therapy, Center for Biological Evaluation and Research, FDA, Bethesda, MD 20892, USA, , , , , , US

    R. Puri

Authors
  1. Y. Chu
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  2. H.-M. Hu
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  3. H. Winter
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  4. W. J. Wood
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  5. T. Doran
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  6. D. Lashley
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  7. J. Bashey
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  8. J. Schuster
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  9. J. Wood
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  10. B. A. Lowe
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  11. J. T. Vetto
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  12. A. D. Weinberg
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  13. R. Puri
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  14. J. W. Smith II
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  15. W. J. Urba
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  16. B. A. Fox
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Chu, Y., Hu, HM., Winter, H. et al. Examining the immune response in sentinel lymph nodes of mice and men. Eur J Nucl Med 26 (Suppl 1), S50–S53 (1999). https://doi.org/10.1007/s002590050578

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  • DOI: https://doi.org/10.1007/s002590050578

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