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Predictive value of 18F-FDG PET/CT in adults with T-cell lymphoblastic lymphoma: post hoc analysis of results from the GRAALL-LYSA LLO3 trial

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Abstract

Purpose

We examined whether FDG PET can be used to predict outcome in patients with lymphoblastic lymphoma (LL).

Methods

This was a retrospective post hoc analysis of data from the GRAAL-LYSA LL03 trial, in which the treatment of LL using an adapted paediatric-like acute lymphoblastic leukaemia protocol was evaluated. PET data acquired at baseline and after induction were analysed. Maximum standardized uptake values (SUVmax), total metabolic tumour volume and total lesion glycolysis were measured at baseline. The relative changes in SUVmax from baseline (ΔSUVmax) and the Deauville score were determined after induction.

Results

The population analysed comprised 36 patients with T-type LL. SUVmax using a cut-off value of ≤8.76 vs. >8.76 was predictive of 3-year event-free survival (31.6% vs. 80.4%; p = 0.013) and overall survival (35.0% vs. 83.7%; p = 0.028). ΔSUVmax using a cut-off value of ≤80% vs. >80% tended also to be predictive of 3-year event-free survival (40.0% vs. 76.0%; p = 0.054) and overall survival (49.2% vs. 85.6%; p = 0.085). Total metabolic tumour volume, baseline total lesion glycolysis and response according to the Deauville score were not predictive of outcome.

Conclusions

A low initial SUVmax was predictive of worse outcomes in our series of patients with T-type LL. Although relatively few patients were included, the study also suggested that ΔSUVmax may be useful for predicting therapeutic efficacy.

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Acknowledgements

Medical writing was provided by Dr. Phillip Leventhal (4Clinics, Paris, France) and paid for by the Centre Henri-Becquerel.

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Authors and Affiliations

  1. Department of Nuclear Medicine, Centre Henri-Becquerel, Rue d’Amiens, 76038, Rouen Cedex, France

    Stéphanie Becker & Pierre Vera

  2. QuantIF–LITIS (EA [Equipe d’Accueil] 4108), Faculty of Medicine, University of Rouen, Rouen, France

    Stéphanie Becker & Pierre Vera

  3. Department of Biostatistics, Rouen University Hospital, Rouen, France

    Thomas Vermeulin

  4. Department of Nuclear Medicine, Hôpital Tenon, AP-HP, Paris, France

    Anne-Ségolène Cottereau

  5. Department of Hematology, Hôpital Saint-Louis, AP-HP, Université Paris Diderot, EA3518, Paris, France

    Nicolas Boissel

  6. Inserm U1245 and Department of Hematology, Centre Henri Becquerel and Normandie Univ UNIROUEN, Rouen, France

    Stéphane Lepretre

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  1. Stéphanie Becker
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  2. Thomas Vermeulin
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Correspondence to Stéphanie Becker.

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Ethical approval

This study was performed in accordance with the principles of the Declaration of Helsinki and local laws, and the protocol was approved by the local Comité de protection des personnes in France and independent ethics committees of each institution in Belgium.

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All patients participating in this study provided written informed consent.

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Becker, S., Vermeulin, T., Cottereau, AS. et al. Predictive value of 18F-FDG PET/CT in adults with T-cell lymphoblastic lymphoma: post hoc analysis of results from the GRAALL-LYSA LLO3 trial. Eur J Nucl Med Mol Imaging 44, 2034–2041 (2017). https://doi.org/10.1007/s00259-017-3776-3

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  • DOI: https://doi.org/10.1007/s00259-017-3776-3

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