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Standardization of metaiodobenzylguanidine heart to mediastinum ratio using a calibration phantom: effects of correction on normal databases and a multicentre study

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European Journal of Nuclear Medicine and Molecular Imaging Aims and scope Submit manuscript

Abstract

Purpose

This study was performed to demonstrate that the results obtained with a calibration phantom could be used as a tool for standardizing measurement of heart to mediastinum (H/M) ratio in cardiac metaiodobenzylguanidine (MIBG) imaging.

Methods

Images of the phantom containing 123I-MIBG were acquired on the cameras in 10 hospitals (11 camera types) to determine the relationship between H/M ratios using different collimators: low-energy (LE) and medium-energy (ME)/low–medium-energy (LME) collimators. The effect of standardization on the ME-comparable H/M ratio was examined in two settings: a Japanese standard MIBG database (n = 62) and multicentre studies (n = 49). In a multicentre study, probable Alzheimer’s disease (AD, n = 18) and probable dementia with Lewy bodies (DLB, n = 31) were studied and standardized by the calibration phantom method.

Results

Linear regression equations between LE and ME collimators were obtained for the phantom study in all institutions. When the H/M ratio with an LE collimator was corrected based upon the calibration phantom, the corrected values were comparable to those obtained using ME collimators. The standard database also exhibited a normal distribution after standardization as determined by skewness and goodness-of-fit test. A mixture of the populations by LE and ME collimators showed significant separation of AD and DLB groups (F ratio = 24.9 for the late H/M), but the corrected values resulted in higher F ratios for both early and late H/M (F ratio = 34.9 for the late H/M).

Conclusion

Standardization of H/M ratios by the heart-chest calibration phantom method is feasible among different collimator types. This method could be practically used for multicentre comparison of H/M ratios.

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Acknowledgment

We thank the physicians and technologists who contributed to the phantom studies and accumulation of the data. This work was supported partly by Grants-in-Aid for Scientific Research in Japan (No. 22591320, P. I. Kenichi Nakajima).

Participating physicians and technologists in a multicentre MIBG standardization project in Japan: Kenichi Nakajima (Chief Investigator, Kanazawa University), Hiroshi Fukuda, Hayato Odagiri (Tohoku University, Sendai), Hidetoshi Morii (Sunagawa City Hospital, Sunagawa), Hiroshi Yokota, Masao Tamura (Tsukuba University Hospital, Tsukuba), Mana Yoshimura, Kenji Uchida, Kunihiko Hirayama (Tokyo Medical University Hospital, Tokyo), Masaru Suzuki, Yumiko Okuyama, Satoshi Kimura, Kenichi Sato (Juntendo University, Tokyo), Kengo Ito, Takashi Kato, Masato Saito (National Center of Geriatrics and Gerontology, Obu), Hidenao Miyoshi, Shigeru Moriyama (Tottori University, Tottori), Shuichi Sugino (Okayama Kyokuto Hospital, Okayama), Chio Okuyama, Takeshi Nii (Kyoto Prefectural University Hospital, Kyoto), Shinro Matsuo, Koichi Okuda, Junichi Taki (Kanazawa University, Kanazawa), Yumiko Kirihara, Takehiro Ishikawa (Fujifilm RI Pharma, Co. Ltd.).

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Correspondence to Kenichi Nakajima.

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Nakajima, K., Okuda, K., Matsuo, S. et al. Standardization of metaiodobenzylguanidine heart to mediastinum ratio using a calibration phantom: effects of correction on normal databases and a multicentre study. Eur J Nucl Med Mol Imaging 39, 113–119 (2012). https://doi.org/10.1007/s00259-011-1963-1

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  • DOI: https://doi.org/10.1007/s00259-011-1963-1

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