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Non-invasive assessment of coronary artery disease with CT coronary angiography and SPECT: a novel dose-saving fast-track algorithm

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European Journal of Nuclear Medicine and Molecular Imaging Aims and scope Submit manuscript

Abstract

Purpose

To validate a new low-dose and rapid stepwise individualized algorithm for non-invasive assessment of ischemic coronary artery disease by sequential use of prospectively ECG-triggered low-dose CT coronary angiography (CTCA) and low-dose single-photon emission computed tomography myocardial perfusion imaging (SPECT-MPI).

Methods

Forty patients referred for elective invasive coronary angiography (CA) were prospectively enrolled to undergo a comprehensive non-invasive evaluation with low-dose CTCA and a dose-reduced stress/rest SPECT-MPI scan (using dedicated reconstruction algorithms for low count scans). The following algorithm was reviewed: CTCA first, followed by a stress-only MPI if a coronary stenosis (≥ 50% diameter narrowing) or equivocal findings were observed. Only abnormal stress MPI scans were followed by rest MPI. The accuracy of the individualized algorithm to predict coronary revascularization and its mean effective radiation dose were assessed.

Results

CTCA documented CAD in 18 and equivocal findings in two patients, thus, requiring additional stress MPI scans. Of these, 16 were abnormal, therefore requiring a rest MPI scan, revealing ischemia in 15 patients. Sensitivity, specificity, negative and positive predictive value, and accuracy of the individualized algorithm for predicting coronary revascularization was 93.3%, 96.0%, 96.0%, 93.3% and 95.0% on a per-patient base. The mean effective radiation dose was significantly lower for the individualized (4.8 ± 3.4 mSv) versus the comprehensive method (8.1 ± 1.5 mSv) resulting in a total population radiation dose reduction of 132.6 mSv.

Conclusion

This new individualized low-dose algorithm allows rapid and accurate prediction of invasive CA findings and of treatment decision with minimized radiation dose.

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Acknowledgements

The study was supported by a grant from the Swiss National Science Foundation and by the ZIHP (Zurich Center for Integrative Human Physiology, University of Zurich, Switzerland). We are grateful to Ennio Mueller, Edlira Loga, Mirjam De Bloeme, Verena Weichselbaumer, and Josephine Trinckauf for their excellent technical support.

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Authors and Affiliations

  1. Cardiac Imaging, University Hospital Zurich, Ramistrasse 100, CH-8091, Zurich, Switzerland

    Aju P. Pazhenkottil, Bernhard A. Herzog, Lars Husmann, Ronny R. Buechel, Irene A. Burger, Ines Valenta, Ulf Landmesser, Christophe A. Wyss & Philipp A. Kaufmann

  2. Zurich Center for Integrative Human Physiology (ZIHP), University of Zurich, Zurich, Switzerland

    Philipp A. Kaufmann

Authors
  1. Aju P. Pazhenkottil
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  2. Bernhard A. Herzog
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  3. Lars Husmann
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  4. Ronny R. Buechel
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  5. Irene A. Burger
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  6. Ines Valenta
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  7. Ulf Landmesser
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  8. Christophe A. Wyss
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  9. Philipp A. Kaufmann
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Corresponding author

Correspondence to Philipp A. Kaufmann.

Additional information

Aju P Pazhenkottil and Bernhard A Herzog contributed equally to this work

Christophe A Wyss and Philipp A Kaufmann shared last authorship

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Pazhenkottil, A.P., Herzog, B.A., Husmann, L. et al. Non-invasive assessment of coronary artery disease with CT coronary angiography and SPECT: a novel dose-saving fast-track algorithm. Eur J Nucl Med Mol Imaging 37, 522–527 (2010). https://doi.org/10.1007/s00259-009-1273-z

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  • DOI: https://doi.org/10.1007/s00259-009-1273-z

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