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Absolute quantitation of myocardial blood flow with 201Tl and dynamic SPECT in canine: optimisation and validation of kinetic modelling

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Abstract

Purpose

201Tl has been extensively used for myocardial perfusion and viability assessment. Unlike 99mTc-labelled agents, such as 99mTc-sestamibi and 99mTc-tetrofosmine, the regional concentration of 201Tl varies with time. This study is intended to validate a kinetic modelling approach for in vivo quantitative estimation of regional myocardial blood flow (MBF) and volume of distribution of 201Tl using dynamic SPECT.

Methods

Dynamic SPECT was carried out on 20 normal canines after the intravenous administration of 201Tl using a commercial SPECT system. Seven animals were studied at rest, nine during adenosine infusion, and four after beta-blocker administration. Quantitative images were reconstructed with a previously validated technique, employing OS-EM with attenuation-correction, and transmission-dependent convolution subtraction scatter correction. Measured regional time-activity curves in myocardial segments were fitted to two- and three-compartment models. Regional MBF was defined as the influx rate constant (K 1) with corrections for the partial volume effect, haematocrit and limited first-pass extraction fraction, and was compared with that determined from radio-labelled microspheres experiments.

Results

Regional time-activity curves responded well to pharmacological stress. Quantitative MBF values were higher with adenosine and decreased after beta-blocker compared to a resting condition. MBFs obtained with SPECT (MBFSPECT) correlated well with the MBF values obtained by the radio-labelled microspheres (MBFMS) (MBFSPECT = −0.067 + 1.042 × MBFMS, p < 0.001). The three-compartment model provided better fit than the two-compartment model, but the difference in MBF values between the two methods was small and could be accounted for with a simple linear regression.

Conclusion

Absolute quantitation of regional MBF, for a wide physiological flow range, appears to be feasible using 201Tl and dynamic SPECT.

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Acknowledgement

This study was supported by the Budget for Nuclear Research of the Ministry of Education, Culture, Sports, and Technology (MEXT), Japan; a grant from the Cooperative Link of Unique Science and Technology for Economy Revitalization promoted by the Ministry of Education, Culture, Sports and Technology, Japan and a grant for translational research from the Ministry of Health, Labour and Welfare (MHLW), Japan. We would like to thank Nihon Medi-Physics, Hyogo, Japan for providing the 201Tl samples and also Mr. Yoshihide Takatani for his invaluable suggestion on the study design.

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Authors and Affiliations

  1. Department of Investigative Radiology, National Cardiovascular Center Research Institute, Fujishiro-dai, Suita City, Osaka, 565-8565, Japan

    Hidehiro Iida, Stefan Eberl, Kyeong-Min Kim, Mayumi Nakazawa, Antti Sohlberg, Tsutomu Zeniya, Takuya Hayashi & Hiroshi Watabe

  2. PET and Nuclear Medicine Department, Royal Prince Alfred Hospital, Missenden Road, Camperdown, NSW, 2050, Australia

    Stefan Eberl

  3. Department of Cardiology, Akita Kumiai General Hospital, 1-1-1, Nishi-bukuro, Iijima, Akita City, 011-0948, Japan

    Yoshikazu Tamura

  4. Akita Research Institute of Brain, 6-10, Senshu-Kubota Machi, Akita City, 010-0874, Japan

    Yukihiko Ono

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  1. Hidehiro Iida
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  2. Stefan Eberl
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  3. Kyeong-Min Kim
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Correspondence to Hidehiro Iida.

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Iida, H., Eberl, S., Kim, KM. et al. Absolute quantitation of myocardial blood flow with 201Tl and dynamic SPECT in canine: optimisation and validation of kinetic modelling. Eur J Nucl Med Mol Imaging 35, 896–905 (2008). https://doi.org/10.1007/s00259-007-0654-4

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  • DOI: https://doi.org/10.1007/s00259-007-0654-4

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