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Auger radiation targeted into DNA: a therapy perspective

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Abstract

Background

Auger electron emitters that can be targeted into DNA of tumour cells represent an attractive systemic radiation therapy goal. In the situation of DNA-associated decay, the high linear energy transfer (LET) of Auger electrons gives a high relative biological efficacy similar to that of α particles. In contrast to α radiation, however, Auger radiation is of low toxicity when decaying outside the cell nucleus, as in cytoplasm or outside cells during blood transport. The challenge for such therapies is the requirement to target a high percentage of all cancer cells. An overview of Auger radiation therapy approaches of the past decade shows several research directions and various targeting vehicles. The latter include hormones, peptides, halogenated nucleotides, oligonucleotides and internalising antibodies.

Discussion

Here, we will discuss the basic principles of Auger electron therapy as compared with vector-guided α and β radiation. We also review some radioprotection issues and briefly present the main advantages and disadvantages of the different targeting modalities that are under investigation.

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Acknowledgements

Preparation of this article was made possible within the frame of research grants from the Swiss National Science Foundation, Nos. 31-67112.01 and 3100AO-110023/1. We also express our gratitude to Mrs. Frances Godson for reviewing the manuscript.

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Authors and Affiliations

  1. Service of Nuclear Medicine, University Hospital of Lausanne CHUV, Rue du Bugnon 46, 1011, Lausanne, Switzerland

    Franz Buchegger, Florence Perillo-Adamer & Angelika Bischof Delaloye

  2. Service of Nuclear Medicine, University Hospital of Lausanne, Lausanne, Switzerland

    Franz Buchegger

  3. Service of Nutrition, University Hospital of Geneva, Geneva, Switzerland

    Yves M. Dupertuis

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  1. Franz Buchegger
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  2. Florence Perillo-Adamer
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  3. Yves M. Dupertuis
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  4. Angelika Bischof Delaloye
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Correspondence to Franz Buchegger.

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Buchegger, F., Perillo-Adamer, F., Dupertuis, Y.M. et al. Auger radiation targeted into DNA: a therapy perspective. Eur J Nucl Med Mol Imaging 33, 1352–1363 (2006). https://doi.org/10.1007/s00259-006-0187-2

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  • DOI: https://doi.org/10.1007/s00259-006-0187-2

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