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Assessment of the role of FDG PET in the diagnosis and management of children with refractory epilepsy

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European Journal of Nuclear Medicine and Molecular Imaging Aims and scope Submit manuscript

Abstract

Purpose

We performed a retrospective analysis of the results of FDG PET scans in children with refractory epilepsy referred to our centre over an 8-year period, with a view to ascertaining the impact of FDG PET on subsequent patient management.

Methods

A questionnaire was used to assess the impact of FDG PET scan on diagnosis, management and clinical decision-making processes for epilepsy surgery from the managing clinician’s perspective. FDG PET scan results were also compared with MRI, EEG and SPECT results and coded according to whether the FDG PET scan provided independent information and localisation of epileptogenic regions.

Results

A total of 118 eligible patients under the age of 14 years were identified, with questionnaires being completed on 113 evaluable patients (96%). The pre-PET management plan consisted of consideration for surgery in 92 patients (81%) and medical therapy for the remaining 21 patients (19%). Managing physicians rated FDG PET as providing information additional to that obtained with other investigations regarding epileptogenic sites in 88 patients (77%). FDG PET had either a minor or a major impact on clinical management in 58 patients (51%), principally with regard to surgical candidacy.

Conclusion

FDG PET has a definite role in the assessment of paediatric patients with refractory epilepsy who are being considered for surgery. In the future, analysis of FDG PET data in specific subpopulations of children with refractory epilepsy may lead to novel insights regarding aetiology.

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Acknowledgements

We would like to acknowledge the contributions made to this study by Dr. Simon Harvey, the staff members of the Centre for PET and the EEG technologists involved in the patient studies.

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Authors and Affiliations

  1. Department of Nuclear Medicine and Centre for PET, University of Melbourne, Melbourne, Australia

    Glenn P. Ollenberger, Amanda J. Byrne, Salvatore U. Berlangieri, Christopher C. Rowe, Kunthi Pathmaraj & Andrew M. Scott

  2. Department of Neurology, University of Melbourne, Melbourne, Australia

    David C. Reutens, Samuel F. Berkovic & Ingrid E. Scheffer

  3. Department of Medicine, University of Melbourne, Melbourne, Australia

    Christopher C. Rowe, David C. Reutens, Samuel F. Berkovic, Ingrid E. Scheffer & Andrew M. Scott

  4. Ludwig Institute for Cancer Research, Austin Hospital, Heidelberg, Victoria, 3084, Australia

    Andrew M. Scott

Authors
  1. Glenn P. Ollenberger
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  2. Amanda J. Byrne
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  3. Salvatore U. Berlangieri
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  4. Christopher C. Rowe
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  5. Kunthi Pathmaraj
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  6. David C. Reutens
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  7. Samuel F. Berkovic
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  8. Ingrid E. Scheffer
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  9. Andrew M. Scott
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Corresponding author

Correspondence to Andrew M. Scott.

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Ollenberger, G.P., Byrne, A.J., Berlangieri, S.U. et al. Assessment of the role of FDG PET in the diagnosis and management of children with refractory epilepsy. Eur J Nucl Med Mol Imaging 32, 1311–1316 (2005). https://doi.org/10.1007/s00259-005-1844-6

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  • DOI: https://doi.org/10.1007/s00259-005-1844-6

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