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Myocardial β-adrenoceptor downregulation in idiopathic dilated cardiomyopathy measured in vivo with PET using the new radioligand (S)-[11C]CGP12388

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European Journal of Nuclear Medicine and Molecular Imaging Aims and scope Submit manuscript

Abstract

Purpose

The β-adrenoceptor (β-AR) plays an important role in heart failure. Recently, the new tracer (S)-[11C]CGP12388 has been developed. It displays excellent properties for investigation of the cardiac β-ARs in vivo with positron emission tomography (PET). Furthermore, the simple production method allows its use in a routine clinical setting. The aim of this study was to investigate whether decreased myocardial β-AR density in patients with idiopathic dilated cardiomyopathy (IDC) can be estimated using (S)-[11C]CGP12388 PET.

Methods

Myocardial β-AR density was investigated in six patients with IDC and six age-matched healthy controls, using (S)-[11C]CGP12388 PET.

Results

β-AR densities of 5.4±1.3 pmol/g (mean ± SD) were observed in patients; these values were significantly lower than those observed in healthy controls (8.4±1.5 pmol/g, p<0.005).

Conclusion

This study indicates that PET with (S)-[11C]CGP12388 is applicable for the measurement of myocardial β-AR density in patients. A highly significant reduction in β-AR density was found in patients with IDC compared with healthy controls.

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Authors and Affiliations

  1. Deparment of Cardiology, Groningen University Hospital, Groningen, The Netherlands

    Richard M. de Jong, Paul K. Blanksma & Dirk J. van Veldhuisen

  2. PET-center, Groningen University Hospital, P.O. Box 30001, 9700, RB Groningen, The Netherlands

    Antoon T. M. Willemsen, Riemer H. J. A. Slart, Aren van Waarde, Willem Vaalburg & Philip H. Elsinga

  3. Medical Center Alkmaar, The Netherlands

    Jan Hein Cornel

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  1. Richard M. de Jong
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  2. Antoon T. M. Willemsen
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  3. Riemer H. J. A. Slart
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  4. Paul K. Blanksma
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  5. Aren van Waarde
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  6. Jan Hein Cornel
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  7. Willem Vaalburg
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  8. Dirk J. van Veldhuisen
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  9. Philip H. Elsinga
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Correspondence to Philip H. Elsinga.

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de Jong, R.M., Willemsen, A.T.M., Slart, R.H.J.A. et al. Myocardial β-adrenoceptor downregulation in idiopathic dilated cardiomyopathy measured in vivo with PET using the new radioligand (S)-[11C]CGP12388. Eur J Nucl Med Mol Imaging 32, 443–447 (2005). https://doi.org/10.1007/s00259-004-1701-z

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  • DOI: https://doi.org/10.1007/s00259-004-1701-z

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