Abstract
Phosphaturic mesenchymal tumor is a rare neoplasm which causes osteomalacia or rickets. The tumor typically follows a benign clinical course. Even in the rare malignant cases, local recurrence and distant metastasis are uncommon. We report on an example of a malignant phosphaturic mesenchymal tumor which recurred several times over 16 years concurrently causing hypophosphatemia, bone pain, and osteomalacia. Following each surgery, symptoms and hypophosphatemia improved. The patient died of disease 17 years after the first surgery. Histologically, the initial tumor was composed of small spindle cells with clusters of giant cells, prominent blood vessels, poorly formed cartilaginous areas, and crystalline material. Cytological atypia was minimal. Following multiple recurrences, the tumor demonstrated areas of high-grade sarcoma exhibiting marked pleomorphism, numerous mitotic figures, and p53 overexpression. This case illustrates the potential lethality of incompletely removed phosphaturic mesenchymal tumors.
Similar content being viewed by others
Author information
Authors and Affiliations
Additional information
Received: 3 January 2000 Revision requested: 4 August 2000 Revision received: 12 October 2000 Accepted: 18 October 2000
Rights and permissions
About this article
Cite this article
Ogose, A., Hotta, T., Emura, I. et al. Recurrent malignant variant of phosphaturic mesenchymal tumor with oncogenic osteomalacia. Skeletal Radiol 30, 99–103 (2001). https://doi.org/10.1007/s002560000306
Issue Date:
DOI: https://doi.org/10.1007/s002560000306