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Extranodal Rosai-Dorfman Disease: a rare presentation involving anterior chest wall in a middle-aged female

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Abstract

Rosai-Dorfman Disease is a rare benign disorder involving overproduction of immune cells, causing swollen lymph nodes and, in rare cases, the sternum. The sternal involvement may cause chest pain and masses. Diagnosis is confirmed through clinical examination, biopsy, and imaging. Treatment options may include surgery, radiation, or steroids. In this case study, we present an unusual example of extranodal Rosai-Dorfman Disease involving the sternum, bilateral clavicles and first three ribs, and pectoral muscle with no associated lymphadenopathy or systemic symptoms in a 57-year-old female. The etiology, pathology, immunohistochemistry, imaging findings, and treatment options of this unique disease are discussed.

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Data Availability

The data presented in this case report contains patient information that is confidential. This confidentiality is maintained to protect the privacy and rights of the individuals whose information is included in the report. Interested parties seeking access to the data should contact the University of Alabama at Birmingham, Heersink School of Medicine, to initiate the necessary permissions and procedures.

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Authors and Affiliations

  1. M.B.B.S., S. P. Medical College, Bikaner, Rajasthan, India

    Abhimanyu Agarwal

  2. Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA

    Aishwarya Ravindran, James Donahue, Isam-Eldin Eltoum & Mostafa Abozeed

  3. Clinical Pathology Department, University of Alabama at Birmingham (UAB), Birmingham, AL, USA

    Aishwarya Ravindran & Isam-Eldin Eltoum

  4. Thoracic Surgery Department, University of Alabama at Birmingham (UAB), Birmingham, AL, USA

    James Donahue

  5. Radiology Department, University of Alabama at Birmingham (UAB), Birmingham, AL, USA

    Mostafa Abozeed

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  1. Abhimanyu Agarwal
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Glossary

CD

Scluster of differentiation

IHC

Immunohistochemistry

OCT2

Octamer binding transcription factor 2

SUV

standardized uptake value

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Agarwal, A., Ravindran, A., Donahue, J. et al. Extranodal Rosai-Dorfman Disease: a rare presentation involving anterior chest wall in a middle-aged female. Skeletal Radiol 53, 589–594 (2024). https://doi.org/10.1007/s00256-023-04427-z

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