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Evaluation of giant cell tumors by diffusion weighted imaging–fractional ADC analysis

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Abstract

Background

A single ADC value is used in clinical practice on multi b-value acquisitions. Low b-value acquisitions are affected by intravoxel incoherent motion, which is dependent on perfusion. Giant cell tumors (GCTs) are known to exhibit early arterial enhancement and low ADC values. Mean, minimum and fractional ADC characteristics of osseous and tenosynovial GCTs are systematically evaluated.

Methods

Tenosynovial and osseous GCTs were included. Each lesion was evaluated on conventional MRI and DWI by two musculoskeletal radiologists. ADC was measured by placing an ROI on the most confluent enhancing portion of the lesion. Fractional and best fit ADC calculations were performed using MATLAB software.

Results

No statistically significant difference was found between tenosynovial and osseous lesions’ ADC values. Mean ADC for all lesions was 1.0 × 10−3 mm2/s (SD = 0.2 × 10−3 mm2/s) and minimum ADC was 0.5 × 10−3 mm2/s (SD = 0.3 × 10−3 mm2/s). Average mean ADC value obtained from B50–B400 slope was 1.1 × 10−3 mm2/s (SD = 0.2 × 10−3 mm2/s), and the average mean ADC value obtained from B400–B800 slope was 0.8 × 10−3 mm2/s (SD = 0.1 × 10−3 mm2/s) [p-value <0.01].

Conclusion

Tenosynovial and osseous GCTs demonstrate similar and low ADC values, which become even lower when using high b-value pairs. Our study also supports the theory of intravoxel incoherent motion that becomes apparent at low b values as related to giant cell tumors, which are known to be hyperperfused.

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Authors and Affiliations

  1. Department of Radiology, Musculoskeletal Imaging, UT Southwestern Medical Center, 5323 Harry Hines Blvd, E230-C, Dallas, TX, 75390-9316, USA

    Oganes Ashikyan, M. Chalian, D. Moore, Y. Xi, P. Pezeshk & A. Chhabra

  2. Department of Orthopedic Surgery, UT Southwestern Medical Center, Dallas, TX, USA

    A. Chhabra

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  1. Oganes Ashikyan
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  2. M. Chalian
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  3. D. Moore
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  4. Y. Xi
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  5. P. Pezeshk
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Correspondence to Oganes Ashikyan.

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Disclosures

O. Ashikyan, MD contributes content to, and his family member owns a business that manages the following websites: www.mridoc.com; www.newagepub.com; www.solrevs.com.

A. Chhabra, MD serves as a consultant with ICON Medical and Treace Medical Inc. A. Chhabra, MD also receives book royalties from Jaypee and Wolters.

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IRB approval

This study was a cross-sectional, retrospective, HIPAA-compliant evaluation that was performed after the institutional review board approval.

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Ashikyan, O., Chalian, M., Moore, D. et al. Evaluation of giant cell tumors by diffusion weighted imaging–fractional ADC analysis. Skeletal Radiol 48, 1765–1773 (2019). https://doi.org/10.1007/s00256-019-03219-8

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  • DOI: https://doi.org/10.1007/s00256-019-03219-8

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