Skip to main content

Advertisement

SpringerLink
Log in

The role of MRI in image-guided needle biopsy of focal bone and soft tissue neoplasms

  • Review Article
  • Published:
Skeletal Radiology Aims and scope Submit manuscript

Abstract

Magnetic resonance imaging (MRI) plays a critical role in the management pathway of both soft tissue and bone neoplasms, from diagnosis through to post-treatment follow-up. There are a wide range of surgical, oncological, and combined treatment regimes but these rely on accurate histopathological diagnosis. This article reviews the role of MRI in the planning of image-guided needle biopsy for suspected soft tissue and bone tumors.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3
Fig. 4
Fig. 5
Fig. 6
Fig. 7
Fig. 8
Fig. 9
Fig. 10
Fig. 11
Fig. 12

Similar content being viewed by others

References

  1. Mankin HJ, Mankin CJ, Simon MA. The hazards of the biopsy, revisited. For the members of the Musculoskeletal Tumor Society. J Bone Joint Surg Am. 1996;78(5):656–63.

    PubMed  CAS  Google Scholar 

  2. Sheppard JE, Switlick DN. Coccidioides immitis osteomyelitis of the radius presenting as Ewing’s sarcoma. Orthopedics. 2008;31(6):607.

    Article  PubMed  Google Scholar 

  3. Sundaram M, McDonald D, Engel E, Rotman M, Siegfried EC. Chronic recurrent multifocal osteomyelitis: an evolving clinical and radiological spectrum. Skeletal Radiol. 1996;25(4):333–6.

    Article  PubMed  CAS  Google Scholar 

  4. Abril JC, Castillo F, Casas J, Díaz A. Brodie’s abscess of the hip simulating osteoid osteoma. Orthopedics. 2000;23(3):285–7.

    PubMed  CAS  Google Scholar 

  5. Yip KM, Lin J, Leung PC. Cystic tuberculosis of the bone mimicking osteogenic sarcoma. Tuber Lung Dis. 1996;77(6):566–8.

    Article  PubMed  CAS  Google Scholar 

  6. Kalbermatten DF, Kalbermatten NT, Siebenrock KA. Osteolytic lesion in the greater trochanter mimicking tumor. Arch Orthop Trauma Surg. 2002;122(1):53–5.

    PubMed  CAS  Google Scholar 

  7. Datir AP. Stress-related bone injuries with emphasis on MRI. Clin Radiol. 2007;62(9):828–36.

    Article  PubMed  CAS  Google Scholar 

  8. Bohndorf K. Infection of the appendicular skeleton. Eur Radiol. 2004;14 Suppl 3:E53–63.

    PubMed  Google Scholar 

  9. Jurik AG. Chronic recurrent multifocal osteomyelitis. Semin Musculoskelet Radiol. 2004;8(3):243–53.

    Article  PubMed  Google Scholar 

  10. Wenger DE, Wold LE. Benign vascular lesions of bone: radiologic and pathologic features. Skeletal Radiol. 2000;29(2):63–74.

    Article  PubMed  CAS  Google Scholar 

  11. Earwaker JWS, Cotten A. SAPHO: syndrome or concept? Imaging findings. Skeletal Radiol. 2003;32(6):311–27.

    Article  PubMed  CAS  Google Scholar 

  12. Laredo J-D, Vuillemin-Bodaghi V, Boutry N, Cotten A, Parlier-Cuau C. SAPHO syndrome: MR appearance of vertebral involvement. Radiology. 2007;242(3):825–31.

    Article  PubMed  Google Scholar 

  13. Crundwell N, O’Donnell P, Saifuddin A. Non-neoplastic conditions presenting as soft-tissue tumours. Clin Radiol. 2007;62(1):18–27.

    Article  PubMed  CAS  Google Scholar 

  14. Boutin RD, Fritz RC, Steinbach LS. Imaging of sports-related muscle injuries. Radiol Clin North Am. 2002;40(2):333–62. vii.

    Article  PubMed  Google Scholar 

  15. Elsayes KM, Lammle M, Shariff A, Totty WG, Habib IF, Rubin DA. Value of magnetic resonance imaging in muscle trauma. Curr Probl Diagn Radiol. 2006;35(5):206–12.

    Article  PubMed  Google Scholar 

  16. Garcia J. MRI in inflammatory myopathies. Skeletal Radiol. 2000;29(8):425–38.

    Article  PubMed  CAS  Google Scholar 

  17. Struk DW, Munk PL, Lee MJ, Ho SG, Worsley DF. Imaging of soft tissue infections. Radiol Clin North Am. 2001;39(2):277–303.

    Article  PubMed  CAS  Google Scholar 

  18. Kransdorf MJ, Murphey MD. Radiologic evaluation of soft-tissue masses: a current perspective. AJR Am J Roentgenol. 2000;175(3):575–87.

    Article  PubMed  CAS  Google Scholar 

  19. Beggs I, Saifuddin A, Limb D. Non-communicating intramuscular ganglia. Eur Radiol. 1998;8(9):1657–61.

    Article  PubMed  CAS  Google Scholar 

  20. Weiss S, Goldblum J. General Considerations. In: Enzinger and Weiss’s soft tissue tumors. Mosby; 2001. p. 1–19.

  21. Sundaram M, McLeod RA. MR imaging of tumor and tumorlike lesions of bone and soft tissue. AJR Am J Roentgenol. 1990;155(4):817–24.

    Article  PubMed  CAS  Google Scholar 

  22. Goodwin RW, O’Donnell P, Saifuddin A. MRI appearances of common benign soft-tissue tumours. Clin Radiol. 2007;62(9):843–53.

    Article  PubMed  CAS  Google Scholar 

  23. Murphey MD, Carroll JF, Flemming DJ, Pope TL, Gannon FH, Kransdorf MJ. From the archives of the AFIP: benign musculoskeletal lipomatous lesions. Radiographics. 2004;24(5):1433–66.

    Article  PubMed  Google Scholar 

  24. Bancroft LW, Kransdorf MJ, Peterson JJ, O’Connor MI. Benign fatty tumors: classification, clinical course, imaging appearance, and treatment. Skeletal Radiol. 2006;35(10):719–33.

    Article  PubMed  Google Scholar 

  25. Ritchie DA, Aniq H, Davies AM, Mangham DC, Helliwell TR. Hibernoma—correlation of histopathology and magnetic-resonance-imaging features in 10 cases. Skeletal Radiol. 2006;35(8):579–89.

    Article  PubMed  CAS  Google Scholar 

  26. Murphey MD, Arcara LK, Fanburg-Smith J. From the archives of the AFIP: imaging of musculoskeletal liposarcoma with radiologic-pathologic correlation. Radiographics. 2005;25(5):1371–95.

    Article  PubMed  Google Scholar 

  27. Vilanova JC, Barceló J, Smirniotopoulos JG, Pérez-Andrés R, Villalón M, Miró J, et al. Hemangioma from head to toe: MR imaging with pathologic correlation. Radiographics. 2004;24(2):367–85.

    Article  PubMed  Google Scholar 

  28. Fayad LM, Fayad L, Hazirolan T, Bluemke D, Mitchell S. Vascular malformations in the extremities: emphasis on MR imaging features that guide treatment options. Skeletal Radiol. 2006;35(3):127–37.

    Article  PubMed  Google Scholar 

  29. Murphey MD, Smith WS, Smith SE, Kransdorf MJ, Temple HT. From the archives of the AFIP. Imaging of musculoskeletal neurogenic tumors: radiologic-pathologic correlation. Radiographics. 1999;19(5):1253–80.

    PubMed  CAS  Google Scholar 

  30. Pilavaki M, Chourmouzi D, Kiziridou A, Skordalaki A, Zarampoukas T, Drevelengas A. Imaging of peripheral nerve sheath tumors with pathologic correlation: pictorial review. Eur J Radiol. 2004;52(3):229–39.

    Article  PubMed  CAS  Google Scholar 

  31. Malghem J, Baudrez V, Lecouvet F, Lebon C, Maldague B, Vande Berg B. Imaging study findings in elastofibroma dorsi. Joint Bone Spine. 2004;71(6):536–41.

    Article  PubMed  Google Scholar 

  32. Priolo F, Cerase A. The current role of radiography in the assessment of skeletal tumors and tumor-like lesions. Eur J Radiol. 1998;27 Suppl 1:S77–85.

    Article  PubMed  Google Scholar 

  33. Berber O, Datta G, Sabharwal S, Aston W, Saifuddin A, Briggs T. The safety of direct primary excision of low-grade chondral lesions based on radiological diagnosis alone. Acta Orthop Belg. 2012;78(2):254–62.

    PubMed  Google Scholar 

  34. Alyas F, James SL, Davies AM, Saifuddin A. The role of MR imaging in the diagnostic characterisation of appendicular bone tumours and tumour-like conditions. Eur Radiol. 2007;17(10):2675–86.

    Article  PubMed  CAS  Google Scholar 

  35. Leung JC, Dalinka MK. Magnetic resonance imaging in primary bone tumors. Semin Roentgenol. 2000;35(3):297–305.

    Article  PubMed  CAS  Google Scholar 

  36. Rechl H, Hof N, Gerdesmeier L. Differential diagnosis of bone and soft tissue tumors by MRI. Orthopade. 2001;30(8):528–39.

    Article  PubMed  CAS  Google Scholar 

  37. O’Donnell P, Saifuddin A. The prevalence and diagnostic significance of fluid-fluid levels in focal lesions of bone. Skeletal Radiol. 2004;33(6):330–6.

    Article  PubMed  Google Scholar 

  38. Robbin MR, Murphey MD. Benign chondroid neoplasms of bone. Semin Musculoskelet Radiol. 2000;4(1):45–58.

    Article  PubMed  CAS  Google Scholar 

  39. Flemming DJ, Murphey MD. Enchondroma and chondrosarcoma. Semin Musculoskelet Radiol. 2000;4(1):59–71.

    Article  PubMed  CAS  Google Scholar 

  40. Murphey MD, Choi JJ, Kransdorf MJ, Flemming DJ, Gannon FH. Imaging of osteochondroma: variants and complications with radiologic-pathologic correlation. Radiographics. 2000;20(5):1407–34.

    PubMed  CAS  Google Scholar 

  41. Campbell RSD, Grainger AJ, Mangham DC, Beggs I, Teh J, Davies AM. Intraosseous lipoma: report of 35 new cases and a review of the literature. Skeletal Radiol. 2003;32(4):209–22.

    Article  PubMed  CAS  Google Scholar 

  42. Parman LM, Murphey MD. Alphabet soup: cystic lesions of bone. Semin Musculoskelet Radiol. 2000;4(1):89–101.

    Article  PubMed  CAS  Google Scholar 

  43. Margau R, Babyn P, Cole W, Smith C, Lee F. MR imaging of simple bone cysts in children: not so simple. Pediatr Radiol. 2000;30(8):551–7.

    Article  PubMed  CAS  Google Scholar 

  44. Mahnken AH, Nolte-Ernsting CCA, Wildberger JE, Heussen N, Adam G, Wirtz DC, et al. Aneurysmal bone cyst: value of MR imaging and conventional radiography. Eur Radiol. 2003;13(5):1118–24.

    PubMed  CAS  Google Scholar 

  45. Rajeswaran G, Malik Q, Saifuddin A. The Role of Needle Biopsy for Focal Bone Lesions with Complete Fluid-Fluid Levels on MRI. Skeletal Radiology. 2013;42(6):765–9.

    Google Scholar 

  46. Bonakdarpour A, Levy WM, Aegerter E. Primary and secondary aneurysmal bone cyst: a radiological study of 75 cases. Radiology. 1978;126(1):75–83.

    PubMed  CAS  Google Scholar 

  47. Van Dyck P, Vanhoenacker FM, Vogel J, Venstermans C, Kroon HM, Gielen J, et al. Prevalence, extension and characteristics of fluid-fluid levels in bone and soft tissue tumors. Eur Radiol. 2006;16(12):2644–51.

    Article  PubMed  Google Scholar 

  48. Alyas F, Lee J, Ahmed M, Connell D, Saifuddin A. Prevalence and diagnostic significance of fluid-fluid levels in soft-tissue neoplasms. Clin Radiol. 2007;62(8):769–74. discussion 775.

    Article  PubMed  CAS  Google Scholar 

  49. Tsai JC, Dalinka MK, Fallon MD, Zlatkin MB, Kressel HY. Fluid-fluid level: a nonspecific finding in tumors of bone and soft tissue. Radiology. 1990;175(3):779–82.

    PubMed  CAS  Google Scholar 

  50. Murphey MD, Nomikos GC, Flemming DJ, Gannon FH, Temple HT, Kransdorf MJ. From the archives of AFIP. Imaging of giant-cell tumor and giant-cell reparative granuloma of bone: radiologic-pathologic correlation. Radiographics. 2001;21(5):1283–309.

    PubMed  CAS  Google Scholar 

  51. Vilanova JC, Woertler K, Narváez JA, Barceló J, Martínez SJ, Villalón M, et al. Soft-tissue tumors update: MR imaging features according to the WHO classification. Eur Radiol. 2007;17(1):125–38.

    Article  PubMed  Google Scholar 

  52. James SLJ, Davies AM. Surface lesions of the bones of the hand. Eur Radiol. 2006;16(1):108–23.

    Article  PubMed  CAS  Google Scholar 

  53. Horcajadas AB, Lafuente JL, de la Cruz Burgos R, Muñiz SH, Roca SA, Ortega SG, et al. Ultrasound and MR findings in tumor and tumor-like lesions of the fingers. Eur Radiol. 2003;13(4):672–85.

    PubMed  Google Scholar 

  54. Narváez JA, Narváez J, Aguilera C, De Lama E, Portabella F. MR imaging of synovial tumors and tumor-like lesions. Eur Radiol. 2001;11(12):2549–60.

    Article  PubMed  Google Scholar 

  55. Cheng XG, You YH, Liu W, Zhao T, Qu H. MRI features of pigmented villonodular synovitis (PVNS). Clin Rheumatol. 2004;23(1):31–4.

    Article  PubMed  Google Scholar 

  56. Masih S, Antebi A. Imaging of pigmented villonodular synovitis. Semin Musculoskelet Radiol. 2003;7(3):205–16.

    Article  PubMed  Google Scholar 

  57. Kroon HM, Bloem JL, Holscher HC, van der Woude HJ, Reijnierse M, Taminiau AH. MR imaging of edema accompanying benign and malignant bone tumors. Skeletal Radiol. 1994;23(4):261–9.

    Article  PubMed  CAS  Google Scholar 

  58. Holscher HC, Bloem JL, Vanel D, Hermans J, Nooy MA, Taminiau AH, et al. Osteosarcoma: chemotherapy-induced changes at MR imaging. Radiology. 1992;182(3):839–44.

    PubMed  CAS  Google Scholar 

  59. James SLJ, Hughes RJ, Ali KE, Saifuddin A. MRI of bone marrow oedema associated with focal bone lesions. Clin Radiol. 2006;61(12):1003–9.

    Article  PubMed  CAS  Google Scholar 

  60. MacSweeney F, Darby A, Saifuddin A. Dedifferentiated chondrosarcoma of the appendicular skeleton: MRI-pathological correlation. Skeletal Radiol. 2003;32(12):671–8.

    Article  PubMed  Google Scholar 

  61. Littrell LA, Wenger DE, Wold LE, Bertoni F, Unni KK, White LM, et al. Radiographic, CT, and MR imaging features of dedifferentiated chondrosarcomas: a retrospective review of 174 de novo cases. Radiographics. 2004;24(5):1397–409.

    Article  PubMed  Google Scholar 

  62. Unni KK, Dahlin DC. Osteosarcoma: pathology and classification. Semin Roentgenol. 1989;24(3):143–52.

    Article  PubMed  CAS  Google Scholar 

  63. Saifuddin A, Mann BS, Mahroof S, Pringle JAS, Briggs TWR, Cannon SR. Dedifferentiated chondrosarcoma: use of MRI to guide needle biopsy. Clin Radiol. 2004;59(3):268–72.

    Article  PubMed  CAS  Google Scholar 

  64. Futani H, Okayama A, Maruo S, Kinoshita G, Ishikura R. The role of imaging modalities in the diagnosis of primary dedifferentiated parosteal osteosarcoma. J Orthop Sci. 2001;6(3):290–4.

    Article  PubMed  CAS  Google Scholar 

  65. Shuhaibar H, Friedman L. Dedifferentiated parosteal osteosarcoma with high-grade osteoclast-rich osteogenic sarcoma at presentation. Skeletal Radiol. 1998;27(10):574–7.

    Article  PubMed  CAS  Google Scholar 

  66. Jelinek JS, Murphey MD, Kransdorf MJ, Shmookler BM, Malawer MM, Hur RC. Parosteal osteosarcoma: value of MR imaging and CT in the prediction of histologic grade. Radiology. 1996;201(3):837–42.

    PubMed  CAS  Google Scholar 

  67. Woertler K, Lindner N, Gosheger G, Brinkschmidt C, Heindel W. Osteochondroma: MR imaging of tumor-related complications. Eur Radiol. 2000;10(5):832–40.

    Article  PubMed  CAS  Google Scholar 

  68. Karasick D, Schweitzer ME, Eschelman DJ. Symptomatic osteochondromas: imaging features. AJR Am J Roentgenol. 1997;168(6):1507–12.

    Article  PubMed  CAS  Google Scholar 

  69. López C, Thomas DV, Davies AM. Neoplastic transformation and tumour-like lesions in Paget’s disease of bone: a pictorial review. Eur Radiol. 2003;13 Suppl 4:L151–63.

    Article  PubMed  Google Scholar 

  70. Saini A, Saifuddin A. MRI of osteonecrosis. Clin Radiol. 2004;59(12):1079–93.

    Article  PubMed  CAS  Google Scholar 

  71. Hermann G, Singson R, Bromley M, Klein MJ, Springfield D, Abdelwahab IF. Cystic degeneration of medullary bone infarction evaluated with magnetic resonance imaging correlated with pathologic examination. Can Assoc Radiol J. 2004;55(5):321–5.

    PubMed  Google Scholar 

  72. Fayad LM, Kawamoto S, Kamel IR, Bluemke DA, Eng J, Frassica FJ, et al. Distinction of long bone stress fractures from pathologic fractures on cross-sectional imaging: how successful are we? AJR Am J Roentgenol. 2005;185(4):915–24.

    Article  PubMed  Google Scholar 

  73. Saifuddin A, Mitchell R, Burnett SJ, Sandison A, Pringle JA. Ultrasound-guided needle biopsy of primary bone tumours. J Bone Joint Surg Br. 2000;82(1):50–4.

    Article  PubMed  CAS  Google Scholar 

  74. Schwartz HS, Spengler DM. Needle tract recurrences after closed biopsy for sarcoma: three cases and review of the literature. Ann Surg Oncol. 1997;4(3):228–36.

    Article  PubMed  CAS  Google Scholar 

Download references

Financial disclosure

The authors have no declarations.

Author information

Authors and Affiliations

  1. Department of Radiology, Royal National Orthopaedic Hospital, Brockley Hill, Stanmore, Middlesex, HA7 4LP, UK

    M. M. Y. Khoo & A. Saifuddin

Authors
  1. M. M. Y. Khoo
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. A. Saifuddin
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to M. M. Y. Khoo.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Khoo, M.M.Y., Saifuddin, A. The role of MRI in image-guided needle biopsy of focal bone and soft tissue neoplasms. Skeletal Radiol 42, 905–915 (2013). https://doi.org/10.1007/s00256-013-1630-7

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00256-013-1630-7

Keywords

Search

Navigation