Skip to main content
SpringerLink
Log in

Tenosynovial giant cell tumor and pigmented villonodular synovitis: a proposal for unification of these clinically distinct but histologically and genetically identical lesions

  • Perspective
  • Published:
Skeletal Radiology Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

References

  1. Ushijima M, Hashimoto H, Tsyneyoshi M, Enjoji M. Giant cell tumor of the tendon sheath (nodular tenosynovitis). A study of 207 cases to compare the large joint group with the common digit group. Cancer 1986;57:1099–107.

    Article  Google Scholar 

  2. Flandry F, Hughston JC. Pigmented villonodular synovitis. Clin Orthop Relat Res 1994;298:212–20.

    PubMed  Google Scholar 

  3. Somerhausen NS, Fletcher CD. Diffuse-type giant cell tumor: clinicopathologic and immunohistochemical analysis of 50 cases with extraarticular disease. Am J Surg Pathol 2000;24:479–92.

    Article  PubMed  CAS  Google Scholar 

  4. West RB, Rubin BP, Miller MA, Subramanian S, Kaygusuz G, Montgomery K, et al. A landscape effect in tenosynovial giant-cell tumor from activation of CSF1 expression by a translocation in a minority of tumor cells. Proc Natl Acad Sci USA 2006;103:690–5.

    Article  PubMed  CAS  Google Scholar 

  5. Sciot R, Rosai J, Dal Cin P, de Wever I, Fletcher CD, Mandahl N, et al. Analysis of 35 cases of localized and diffuse tenosynovial giant cell tumor: a report from the Chromosomes and Morphology (CHAMP) study group. Mod Pathol 1999;12:576–9.

    PubMed  CAS  Google Scholar 

  6. Nilsson M, Hoglund M, Panagopoulos I, Sciot R, Dal Cin P, Debiec-Rychter M, et al. Molecular cytogenetic mapping of recurrent chromosomal breakpoints in tenosynovial giant cell tumors. Virchows Arch 2002;441:475–80.

    Article  PubMed  CAS  Google Scholar 

  7. Jaffe H, Lichtenstein L, Sutro C. Pigmented villonodular synovitis, bursitis and tenosynovitis: a discussion of the synovial and bursal equivalents of the tenosynovial lesion commonly denoted as xanthoma, xanthogranuloma, giant cell tumor or myeloplaxoma of tendon sheath with some consideration of this tendon sheath lesion itself. Arch Pathol 1941;31:731–65.

    Google Scholar 

  8. Lee M, Mahroof S, Pringle J, Short SC, Briggs TW, Cannon SR. Diffuse pigmented villonodular synovitis of the foot and ankle treated with surgery and radiotherapy. Int Orthop 2005;29:403–5.

    Article  PubMed  CAS  Google Scholar 

  9. Talpaz M, Silver RT, Druker BJ, Goldman JM, Gambacorti-Passerini C, Guilhot F, et al. Imatinib induces durable hematologic and cytogenetic responses in patients with accelerated phase chronic myeloid leukemia: results of a phase 2 study. Blood 2002;15:1928–37.

    Article  Google Scholar 

  10. Demetri GD, von Mehren M, Blanke CD, Van den Abbeele AD, Eisenberg B, Roberts PJ, et al. Efficacy and safety of imatinib mesylate in advanced gastrointestinal stromal tumors. N Engl J Med 2002;347:472–80.

    Article  PubMed  CAS  Google Scholar 

  11. Atkins M, Jones CA, Kirkpatrick P. Sunitinib maleate. Nat Rev Drug Discov 2006;5:279–80.

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Departments of Anatomic Pathology and Molecular Genetics, Taussig Cancer Center and Lerner Research Institute, The Cleveland Clinic L25, 9500 Euclid Avenue, Cleveland, OH, 44195, USA

    Brian P. Rubin

Authors
  1. Brian P. Rubin
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Brian P. Rubin.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Rubin, B.P. Tenosynovial giant cell tumor and pigmented villonodular synovitis: a proposal for unification of these clinically distinct but histologically and genetically identical lesions. Skeletal Radiol 36, 267–268 (2007). https://doi.org/10.1007/s00256-006-0249-3

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00256-006-0249-3

Search

Navigation