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MRI features of extraskeletal myxoid chondrosarcoma

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Abstract

Objective

To describe the MRI features of extraskeletal myxoid chondrosarcoma in comparison with clinicopathologic findings.

Design and patients

The study comprised 12 male subjects and seven female subjects with a mean age of 53 years (range 16–76 years). MRI findings, evaluated by two radiologists with agreement by consensus, were compared for histopathologic features.

Results

The tumor size ranged from 2.0 cm to 20.0 cm (mean 8.9 cm). Fusion gene transcripts could be detected in 13 (68%) of the 19 cases: EWS-CHN in nine cases, TAF2N-CHN in three, and TFG-TCH in one. There were six fusion-negative cases. Signal characteristics on T1-weighted and T2-weighted MR images were non-specific with regard to each cytogenetic variant. Peripheral enhancement was seen more frequently in tumors with the EWS-CHN variant than in those with other cytogenetic variants. The characteristic pattern of enhancement corresponded to the presence of fibrous septa and peripheral areas of high cellularity within lobules, by correlation with pathologic findings. All cases with TAF2N-CHN or TFG-TCH variants showed invasion of extracompartmental structure, bone, or vessels.

Conclusion

Extraskeletal myxoid chondrosarcoma is an uncommon soft-tissue malignancy that may be recognized by MRI features of multi-lobular soft-tissue mass often invading extracompartmental, bony, and vascular structures.

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Authors and Affiliations

  1. Division of Diagnostic Radiology, National Cancer Center Hospital, 5-1-1, Tsukiji, Chuo-Ku, 104-0045, Tokyo, Japan

    Ukihide Tateishi & Yasuaki Arai

  2. Department of Clinical Pathology, Sapporo Medical University School of Medicine, Sapporo, Japan

    Tadashi Hasegawa

  3. Department of Pathology, Kanazawa Medical University, Ishikawa, Japan

    Takayuki Nojima

  4. Division of Molecular Oncology and Virology, Medical Research Institute, Kanazawa Medical University, Ishikawa, Japan

    Tsutomu Takegami

Authors
  1. Ukihide Tateishi
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  2. Tadashi Hasegawa
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  3. Takayuki Nojima
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  4. Tsutomu Takegami
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  5. Yasuaki Arai
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Corresponding author

Correspondence to Ukihide Tateishi.

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All authors of this research paper have directly participated in the planning, execution, or analysis of the study

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Tateishi, U., Hasegawa, T., Nojima, T. et al. MRI features of extraskeletal myxoid chondrosarcoma. Skeletal Radiol 35, 27–33 (2006). https://doi.org/10.1007/s00256-005-0021-0

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  • DOI: https://doi.org/10.1007/s00256-005-0021-0

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