Abstract
Growth of Streptomyces hygroscopicus under conditions of simulated microgravity in a rotating-wall bioreactor resulted in a pellet form of growth, lowered dry cell weight, and inhibition of rapamycin production. With the addition of Teflon beads to the bioreactor, growth became much less pelleted, dry cell weight increased but rapamycin production was still markedly inhibited. Growth under simulated microgravity favored extracellular production of rapamycin, in contrast to a greater percentage of cell-bound rapamycin observed under normal gravity conditions.
Similar content being viewed by others
Author information
Authors and Affiliations
Additional information
Received: 20 September 1999 / Received revision: 18 November 1999 / Accepted: 19 November 1999
Rights and permissions
About this article
Cite this article
Fang, A., Pierson, D., Mishra, S. et al. Growth of Streptomyces hygroscopicus in rotating-wall bioreactor under simulated microgravity inhibits rapamycin production. Appl Microbiol Biotechnol 54, 33–36 (2000). https://doi.org/10.1007/s002539900303
Issue Date:
DOI: https://doi.org/10.1007/s002539900303