Abstract
Analysis of the metabolic network of lysine-producing Corynebacterium glutamicum showed that lysine yields are limited by the excess energy production in lysine biosynthesis. The most probable maximum yield is 0.47 mol/mol on glucose, when phosphoenolpyruvate carboxylase functions in an anaplerotic rection. When this function is fulfilled by the glyoxylate pathway, a maximum yield of 0.38 mol/mol is obtained.
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de Hollander, J.A. Potential metabolic limitations in lysine production by Corynebacterium glutamicum as revealed by metabolic network analysis. Appl Microbiol Biotechnol 42, 508–515 (1994). https://doi.org/10.1007/BF00173913
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DOI: https://doi.org/10.1007/BF00173913