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The DprE1 enzyme, one of the most vulnerable targets of Mycobacterium tuberculosis

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Abstract

The re-emergence of tuberculosis in recent years led the World Health Organization (WHO) to launch the Stop TB Strategy program. Beside repurposing the existing drugs and exploring novel molecular combinations, an essential step to face the burden of tuberculosis will be to develop new drugs by identifying vulnerable bacterial targets. Recent studies have focused on decaprenylphosphoryl-d-ribose oxidase (DprE1) of Mycobacterium tuberculosis, an essential enzyme involved in cell wall metabolism, for which new promising molecules have proved efficacy as antitubercular agents. This review summarizes the state of the art concerning DprE1 in terms of structure, enzymatic activity and inhibitors. This enzyme is emerging as one of the most vulnerable target in M. tuberculosis.

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Acknowledgments

This work was supported by European Commission (VII Framework, contract no. 260872).

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Authors and Affiliations

  1. Department of Biology and Biotechnology “Lazzaro Spallanzani”, University of Pavia, via Ferrata 1, 27100, Pavia, Italy

    Giovanna Riccardi, Maria Rosalia Pasca, Laurent Roberto Chiarelli, Andrea Mattevi & Claudia Binda

  2. School of Life Sciences, Swiss Federal Institute of Technology in Lausanne (EPFL), 1015, Lausanne, Switzerland

    Giulia Manina

Authors
  1. Giovanna Riccardi
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  2. Maria Rosalia Pasca
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  3. Laurent Roberto Chiarelli
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  4. Giulia Manina
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  5. Andrea Mattevi
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  6. Claudia Binda
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Correspondence to Giovanna Riccardi.

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Riccardi, G., Pasca, M.R., Chiarelli, L.R. et al. The DprE1 enzyme, one of the most vulnerable targets of Mycobacterium tuberculosis . Appl Microbiol Biotechnol 97, 8841–8848 (2013). https://doi.org/10.1007/s00253-013-5218-x

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  • DOI: https://doi.org/10.1007/s00253-013-5218-x

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