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Bio-based production of the platform chemical 1,5-diaminopentane

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Abstract

In the rising era of bio-economy, the five carbon compound 1,5-diaminopentane receives increasing interest as platform chemical, especially as innovative building block for bio-based polymers. The vital interest in bio-based supply of 1,5-diaminopentane has strongly stimulated research on the development of engineered producer strains. Based on the state-of-art knowledge on the pathways and reactions linked to microbial 1,5-diaminopentane metabolism, the review covers novel systems metabolic engineering approaches towards hyper-producing cell factories of Corynebacterium glutamicum or Escherichia coli. This is integrated into the whole value chain from renewable feedstocks via 1,5-diaminopentane to innovative biopolymers involving bioprocess engineering considerations for economic supply.

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Acknowledgments

The authors gratefully acknowledge support by the BMBF-Grant “Biobased Polyamides through Fermentation” (No 0315239A). We further thank Dr. Guido Melzer (Institute of Biochemical Engineering, TU Braunschweig) for calculation of optimal diaminopentane yields.

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  1. Institute of Biochemical Engineering, Technische Universität Braunschweig, Gaussstrasse 17, 38106, Braunschweig, Germany

    Stefanie Kind & Christoph Wittmann

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  1. Stefanie Kind
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  2. Christoph Wittmann
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Correspondence to Christoph Wittmann.

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Kind, S., Wittmann, C. Bio-based production of the platform chemical 1,5-diaminopentane. Appl Microbiol Biotechnol 91, 1287–1296 (2011). https://doi.org/10.1007/s00253-011-3457-2

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  • DOI: https://doi.org/10.1007/s00253-011-3457-2

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