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A polysaccharide–peptide complex from abalone mushroom (Pleurotus abalonus) fruiting bodies increases activities and gene expression of antioxidant enzymes and reduces lipid peroxidation in senescence-accelerated mice

  • Applied Microbial and Cell Physiology
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Abstract

The antioxidant effects of a polysaccharide–peptide complex (F22) from mushroom (Pleurotus abalonus)-fruiting bodies were studied. The activities of superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx) in the liver, kidney, and brain of senescence-accelerated mice showed a marked increase after treatment with the polysaccharide–peptide complex. Concurrently, the gene expression levels of SOD, CAT, and GPx, as determined with real-time polymerase chain reaction, were up-regulated in the liver, kidney, and brain, whereas the MDA content in these organs declined. The maximal lifespan of the mice was prolonged.

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Acknowledgments

Funding from the National Natural Science Foundation (grant no. 30570051) and Tianjin Natural Science Foundation (grant no. 06YFJMJC07500) is gratefully acknowledged.

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Authors and Affiliations

  1. Department of Microbiology, College of Life Science, Nankai University, Tianjin, China

    L. Li, M. Song, F. Yuan, Z. K. Liu, C. L. Wang, Y. Jiang, M. Fu & F. Liu

  2. Department of Biochemistry, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong, China

    T. B. Ng

  3. Tianjin Key Laboratory of Microbial Functional, Genomics, Tianjin, China

    F. Liu

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  1. L. Li
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  2. T. B. Ng
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  3. M. Song
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  4. F. Yuan
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  5. Z. K. Liu
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  6. C. L. Wang
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  7. Y. Jiang
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  8. M. Fu
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  9. F. Liu
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Correspondence to T. B. Ng or F. Liu.

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Li, L., Ng, T.B., Song, M. et al. A polysaccharide–peptide complex from abalone mushroom (Pleurotus abalonus) fruiting bodies increases activities and gene expression of antioxidant enzymes and reduces lipid peroxidation in senescence-accelerated mice. Appl Microbiol Biotechnol 75, 863–869 (2007). https://doi.org/10.1007/s00253-007-0865-4

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  • DOI: https://doi.org/10.1007/s00253-007-0865-4

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