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Pathways and regulation of bacterial arginine metabolism and perspectives for obtaining arginine overproducing strains

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Abstract

l-Arginine is produced by bacterial fermentation and is consumed in food flavoring and pharmaceutical industries. A better understanding of arginine metabolism in bacteria could be beneficial for a rational design of recombinant l-arginine producers by genetic engineering. This mini-review illustrated the current status of genes and enzymes for arginine metabolism, including biosynthetic pathways, catabolic pathways, uptake and excretion systems, and regulation. The linkage of polyamine and glutamate metabolism to the arginine network was also discussed, followed by a perspective view on how to construct arginine overproducing strains of bacteria with increasing biosynthesis and excretion and decreasing catabolism and uptake.

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Acknowledgements

The author is grateful to John E. Houghton for critical reading and to Zhe Yang for the excellent artwork of the manuscript. Research in the author's laboratory was supported by the National Science Foundation grant no. 0415608.

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    Chung-Dar Lu

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Lu, CD. Pathways and regulation of bacterial arginine metabolism and perspectives for obtaining arginine overproducing strains. Appl Microbiol Biotechnol 70, 261–272 (2006). https://doi.org/10.1007/s00253-005-0308-z

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