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Identification of a new quantitative trait locus on Chromosome 7 controlling disease severity of collagen-induced arthritis in rats

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Abstract

 Autoimmune diseases, such as rheumatoid arthritis, Crohn's disease, and multiple sclerosis, are regulated by multiple genes. Major histocompatibility complex (MHC) genes have the strongest effects, but non-MHC genes also contribute to disease susceptibility/severity. In this paper, we describe a new non-MHC quantitative trait locus, Cia8, on rat Chromosome (Chr) 7 that controls collagen-induced arthritis severity in F2 progeny of DA and F344 inbred rats, and present an updated localization of Cia4 on the same chromosome. We also describe the location of mouse and human genes, orthologous to the genes in the genomic intervals containing Cia4 and Cia8, and provide evidence that the segment of rat Chr 7 containing Cia4 and Cia8 is homologous to segments of mouse Chr 10 and 15 and human Chr 8, 12, and 19.

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Authors and Affiliations

  1. Inflammatory Joint Diseases Section, Arthritis and Rheumatism Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes Of Health, Bldg. 10, Room 9N240, 10 Center Drive MSC 1820, Bethesda, MD 20892, USA e-mail: wilderr@arb.niams.nih.gov, Tel.: +1-301-4963373, Fax: +1-301-4020012, , , , , , US

    Svetlana V. Dracheva, Elaine F. Remmers, Yutaka Kawahito, Ryan E. Longman & R. L. Wilder

  2. Research Service, Veterans Affairs Medical Center and Department of Medicine/Rheumatology, University of Utah, Salt Lake City, UT 84132, USA, , , , , , US

    Van R. Reese, Grant W. Cannon & Marie M. Griffiths

  3. Division of Autoimmune and Molecular Diseases, Columbia University College of Physicians and Surgeons, 630 West 168th Street, New York, NY 10032, USA, , , , , , US

    Pércio S. Gulko

Authors
  1. Svetlana V. Dracheva
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  2. Elaine F. Remmers
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  3. Pércio S. Gulko
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  4. Yutaka Kawahito
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  5. Ryan E. Longman
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  6. Van R. Reese
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  7. Grant W. Cannon
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  8. Marie M. Griffiths
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  9. R. L. Wilder
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Additional information

Received: 1 November 1998 / Revised: 24 January 1999

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Dracheva, S., Remmers, E., Gulko, P. et al. Identification of a new quantitative trait locus on Chromosome 7 controlling disease severity of collagen-induced arthritis in rats. Immunogenetics 49, 787–791 (1999). https://doi.org/10.1007/s002510050552

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  • DOI: https://doi.org/10.1007/s002510050552

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