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Detection of a new cerebral malaria susceptibility locus, using CBA mice

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Abstract

Human cerebral malaria (CM) during acute Plasmodium falciparum infection is a serious neurological complication that leads to coma and death. P. berghei ANKA infection of CBA mice is a useful experimental model of CM. To identify host susceptibility loci, we performed chromosomal mapping in crossbred populations of both CM-susceptible CBA and CM-resistant DBA/2 mice. One significant region for a CM-susceptible locus in CBA mice was mapped to H2 region on Chromosome 17, tentatively designated cmsc. cmsc was mapped to a different chromosomal region from that previously reported in the C57BL/6 mouse model of CM. It is possible that different loci contribute to CM in CBA and C57BL/6 mouse strains. Comparison of the function of CM susceptibility loci between CBA and C57BL/6 mice could have important implications for the study of the complex pathogenesis of CM in humans.

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Acknowledgements

This work was supported by a Grant-In-Aid for Encouragement of Young Scientists from the Ministry of Education, Science, Sports and Culture, Japan

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Authors and Affiliations

  1. Division of Experimental Animals, Center for Promotion of Medical Research and Education, Graduate School of Medicine, Nagoya University, 65 Tsurumai-cho, Showa-ku, Nagoya, 466-8550, Japan

    Tamio Ohno & Masahiko Nishimura

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  1. Tamio Ohno
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  2. Masahiko Nishimura
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Correspondence to Tamio Ohno.

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Ohno, T., Nishimura, M. Detection of a new cerebral malaria susceptibility locus, using CBA mice. Immunogenetics 56, 675–678 (2004). https://doi.org/10.1007/s00251-004-0739-1

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  • DOI: https://doi.org/10.1007/s00251-004-0739-1

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