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Association study between interleukin-12 receptor β1/β2 genes and type 1 diabetes or asthma in the Japanese population

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Abstract

Interleukin-12 (IL-12) secreted from macrophages or dendritic cells plays an important role in the protection against intracellular pathogens as well as the developmental commitment of T helper 1 cells. IL-12 exerts its biological effects through binding to specific IL-12 receptors (IL-12Rs) termed IL-12Rβ1 and IL 12Rβ2. In this paper, we performed association studies between the three reported polymorphisms (Q214R, M365T and G378R) of the IL-12Rβ1 gene or the newly identified polymorphisms (P238L, IVS9 −7G>A, IVS13 –121G>A, A643T, P779P and c.3283T>G) of the IL-12Rβ2 gene, and the development of type 1 diabetes or atopic asthma as representative Th1- and Th2- dominant diseases, respectively. The association study of each polymorphism of the IL-12Rβ1 or IL-12Rβ2 gene and type 1 diabetes or asthma showed that these IL-12R genes did not contribute to the development of type 1 diabetes or asthma in the Japanese population. Further analysis in individuals with susceptibility to intracellular pathogens may elucidate the importance of the IL-12R genes.

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Fig. 1A, B.

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Acknowledgements

This work was supported by a Grant-in Aid for Scientific Research (B) from the Ministry of Education, Culture, Sports, Science, and Technology of Japan, and a grant from the Japan Study Group for Pediatric and Adolescent Diabetes.

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Authors and Affiliations

  1. Department of Pediatrics, Graduate School of Medical Sciences, Kyushu University, 3–1-1 Maidashi, Higashi-Ku, 812 8582, Fukuoka , Japan

    Wafaa M Bassuny, Kenji Ihara, Junko Kimura, Shigeki Ichikawa, Ryuichi Kuromaru, Kenichi Miyako, Kouichi Kusuhara, Yuka Sasaki & Toshiro Hara

  2. Department of Endocrinology and Metabolism, Fukuoka Children's Hospital, Fukuoka, Japan

    Hitoshi Kohno

  3. Department of Pediatrics, Kitasato University School of Medicine, Sagamihara, Japan

    Nobuo Matsuura

  4. National Minami-Fukuoka Chest Hospital, Fukuoka, Japan

    Sankei Nishima

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  1. Wafaa M Bassuny
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  2. Kenji Ihara
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  3. Junko Kimura
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  9. Hitoshi Kohno
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  10. Nobuo Matsuura
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  11. Sankei Nishima
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  12. Toshiro Hara
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Correspondence to Wafaa M Bassuny.

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Bassuny, W.M., Ihara, K., Kimura, J. et al. Association study between interleukin-12 receptor β1/β2 genes and type 1 diabetes or asthma in the Japanese population. Immunogenetics 55, 189–192 (2003). https://doi.org/10.1007/s00251-003-0568-7

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  • DOI: https://doi.org/10.1007/s00251-003-0568-7

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