Abstract.
Non-human primates could prove to be suitable models for the study of infectious diseases such as malaria, tuberculosis, and hepatitis; the molecules of their immune systems are in the process of being fully characterized. Due to the relevance of cytokines in the modulation of the immune response, a molecular analysis of these proteins in non-human primates from the Aotus genus was carried out. Peripheral blood mononuclear cells from four species of Aotus monkey were obtained and their mRNAs for interleukin-2 (IL-2), IL-4, IL-6, IL-10, interferon-γ (IFN), and tumor necrosis factor (TNF)-α were characterized. This study shows a high degree of conservation between nucleotide and amino acid sequences of cytokines from different Aotus species and those from humans. The TNF-α molecules were identical in amino acid sequences for both.
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Hernández, E.C., Suárez, C.F., Méndez, J.A. et al. Identification, cloning, and sequencing of different cytokine genes in four species of owl monkey. Immunogenetics 54, 645–653 (2002). https://doi.org/10.1007/s00251-002-0512-2
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DOI: https://doi.org/10.1007/s00251-002-0512-2