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High frequency of MIC null haplotype (HLA-B48-MICA-del-MICB*0107 N) in the Angaite Amerindian community in Paraguay

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Abstract.

We describe a high frequency of the MIC null haplotype, HLA-B48-MICA-del-MICB*0107 N, in the Angaite Amerindian community in Paraguay. Of the 16 unrelated subjects, 9 (56.5%) had this haplotype. The structural analyses revealed this haplotype was similar to the previously reported Asian haplotype in that they had a large-scale deletion including the entire MICA gene and linked to MICB*0107 N and HLA-B*48. The novel recombination haplotype between this MIC null haplotype and HLA-B15, HLA-B15-MICA-del-MICB*0107 N, was also found in this community.

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Authors and Affiliations

  1. Department of Medical Zoology, Saitama Medical School, Moroyama, Saitama, 350–0495, Japan, , , , ,

    Kayano Aida

  2. Departamento de Biologia Molecular, Instituto de Investigaciones en Ciencias de la Salud, Universidad Nacional de Asuncion, Paraguay, , , , ,

    Graciela Russomando, Norma Candia, Leticia Franco & Maria Almiron

  3. Department of Molecular Immunogenetics, Institute of Tropical Medicine, Nagasaki University, Sakamoto, Nagasaki 852–8523, Japan, , , , ,

    Mihoko Kikuchi, Ratawan Ubalee & Kenji Hirayama

Authors
  1. Kayano Aida
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  2. Graciela Russomando
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  3. Mihoko Kikuchi
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  4. Norma Candia
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  5. Leticia Franco
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  6. Maria Almiron
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  7. Ratawan Ubalee
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  8. Kenji Hirayama
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Aida, K., Russomando, G., Kikuchi, M. et al. High frequency of MIC null haplotype (HLA-B48-MICA-del-MICB*0107 N) in the Angaite Amerindian community in Paraguay. Immunogenetics 54, 439–441 (2002). https://doi.org/10.1007/s00251-002-0485-1

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  • DOI: https://doi.org/10.1007/s00251-002-0485-1

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