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A new method for protein domain recognition

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Abstract

A fuzzy cluster method is presented to recognize protein domains. This algorithm can identify domains globally. A protein structure set was used to test the algorithm. Among 219 proteins, 66.7% yielded results that agreed with the reference definitions, 30.6% showed minor differences, and only 2.7% (six proteins) showed major differences with the reference. The new method is more than 20 times fast than previous algorithms.

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Authors and Affiliations

  1. Protein Engineering Laboratory, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, P.R. China e-mail: chenrs@sun5.ibp.ac.cn, , , , , , CN

    Zhen-Yu Xuan, Lun-Jiang Ling & Run-Sheng Chen

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  1. Zhen-Yu Xuan
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  2. Lun-Jiang Ling
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  3. Run-Sheng Chen
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Received: 9 November 1998 / Revised version: 20 December 1999 / Accepted: 20 December 1999

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Xuan, ZY., Ling, LJ. & Chen, RS. A new method for protein domain recognition. Eur Biophys J 29, 7–16 (2000). https://doi.org/10.1007/s002490050246

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  • DOI: https://doi.org/10.1007/s002490050246

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