Abstract
Juvenile idiopathic arthritis (JIA) is the most common rheumatic entity of childhood. The hallmark feature of all subtypes is joint inflammation. Imaging is used to evaluate the extent and severity of inflammation, degree of joint damage and response to treatment, which in turn impacts patient management. Ultrasound has become a useful adjunct to clinical examination because it shows promise in evaluating clinical and subclinical inflammation (synovitis, enthesitis) as well as cartilage and bone erosive changes. However more collaborative research is needed to help define the normal appearance of the growing skeleton, clarify the significance of subclinical findings and develop useful definitions, imaging protocols and scoring systems of disease.
Similar content being viewed by others
References
Ording Muller LS, Humphries P, Rosendahl K (2015) The joints in juvenile idiopathic arthritis. Insights Imaging 6:275–284
Sheybani EF, Khanna G, White AJ et al (2013) Imaging of juvenile idiopathic arthritis: a multimodality approach. Radiographics 33:1253–1273
Magni-Manzoni S (2016) Ultrasound in juvenile idiopathic arthritis. Pediatr Rheumatol Online J 14:33
Magni-Manzoni S, Malattia C, Lanni S et al (2012) Advances and challenges in imaging in juvenile idiopathic arthritis. Nat Rev Rheumatol 8:329–336
Petty RE, Southwood TR, Manners P et al (2004) International League of Associations for rheumatology classification of juvenile idiopathic arthritis: second revision, Edmonton, 2001. J Rheumatol 31:390–392
Ravelli A, Martini A (2007) Juvenile idiopathic arthritis. Lancet 369:767–778
Ramos PC, Ceccarelli F, Jousse-Joulin S (2012) Role of ultrasound in the assessment of juvenile idiopathic arthritis. Rheumatology 51:vii10–12
Prakken B, Albani S, Martini A (2011) Juvenile idiopathic arthritis. Lancet 377:2138–2149
Pruthi S, Thapa MM (2009) Infectious and inflammatory disorders. Magn Reson Imaging Clin N Am 17:423–438
Miller E, Doria AS (2010) Imaging for early assessment of peripheral joints in juvenile idiopathic arthritis. In: Medina LS, Applegate KE, Blackmore CC (eds) Evidence-based imaging in pediatrics: improving the quality of imaging in patient care. Springer, New York, pp 219–244
Collado P, Jousse-Joulin S, Alcalde M et al (2012) Is ultrasound a validated imaging tool for the diagnosis and management of synovitis in juvenile idiopathic arthritis? A systematic literature review. Arthritis Care Res 64:1011–1019
Avenarius DF, Ording Muller LS, Rosendahl K (2016) Erosion or normal variant? 4-year MRI follow-up of the wrists in healthy children. Pediatr Radiol 46:322–330
Roth J, Jousse-Joulin S, Magni-Manzoni S et al (2015) Definitions for the sonographic features of joints in healthy children. Arthritis Care Res 67:136–142
Chauvin NA, Ho-Fung V, Jaramillo D et al (2015) Ultrasound of the joints and entheses in healthy children. Pediatr Radiol 45:1344–1354
Keshava SN, Gibikote SV, Mohanta A et al (2015) Ultrasound and magnetic resonance imaging of healthy paediatric ankles and knees: a baseline for comparison with haemophilic joints. Haemophilia 21:e210–e222
Spannow AH, Pfeiffer-Jensen M, Andersen NT et al (2010) Ultrasonographic measurements of joint cartilage thickness in healthy children: age- and sex-related standard reference values. J Rheumatol 37:2595–2601
Spannow AH, Stenboeg E, Pfeiffer-Jensen M et al (2011) Ultrasound and MRI measurements of joint cartilage in healthy children: a validation study. Ultraschall Med 32:S110–S116
Tse SM, Laxer RM, Babyn PS et al (2006) Radiologic improvement of juvenile idiopathic arthritis-enthesitis-related arthritis following anti-tumor necrosis factor-alpha blockade with etanercept. J Rheumatol 33:1186–1188
Visser K, Katchamart W, Loza E et al (2009) Multinational evidence-based recommendations for the use of methotrexate in rheumatic disorders with a focus on rheumatoid arthritis: integrating systematic literature research and expert opinion of a broad international panel of rheumatologists in the 3E initiative. Ann Rheum Dis 68:1086–1093
Roth J, Ravagnani V, Backhaus M et al (2016) Preliminary definitions for the sonographic features of synovitis in children. Arthritis Care Res. doi:10.1002/acr.23130
Moller I, Loza E, Uson J et al (2016) Recommendations for the use of ultrasound and magnetic resonance in patients with rheumatoid arthritis. Reumatol Clin. doi:10.1016/j.reuma.2016.08.010
D'Agostino MA, Conaghan PG, Naredo E et al (2009) The OMERACT ultrasound task force — advances and priorities. J Rheumatol 36:1829–1832
Nusman CM, Ording Muller LS, Hemke R et al (2016) Current status of efforts on standardizing magnetic resonance imaging of juvenile idiopathic arthritis: report from the OMERACT MRI in JIA working group and health-e-child. J Rheumatol 43:239–244
Colebatch-Bourn AN, Edwards CJ, Collado P et al (2015) EULAR-PReS points to consider for the use of imaging in the diagnosis and management of juvenile idiopathic arthritis in clinical practice. Ann Rheum Dis 74:1946–1957
Hemke R, Doria AS, Tzaribachev N et al (2014) Selecting magnetic resonance imaging (MRI) outcome measures for juvenile idiopathic arthritis (JIA) clinical trials: first report of the MRI in JIA special interest group. J Rheumatol 41:354–358
Lee MJ, Chow K (2007) Ultrasound of the knee. Semin Musculoskelet Radiol 11:137–148
Johnson K (2006) Imaging of juvenile idiopathic arthritis. Pediatr Radiol 36:743–758
Doria AS, Kiss MH, Lotito AP et al (2001) Juvenile rheumatoid arthritis of the knee: evaluation with contrast-enhanced color Doppler ultrasound. Pediatr Radiol 31:524–531
Mouterde G, Carotti M, D'Agostino MA (2009) Contrast-enhanced ultrasound in musculoskeletal diseases. J Radiol 90:148–155
Doria AS, Karshafian R, Moineddin R et al (2006) Contrast-enhanced triggered harmonic sonography for assessment of periarticular hemodynamic changes in experimental arthritis. Pediatr Radiol 36:1242–1251
Weiss PF, Chauvin NA, Roth J (2016) Imaging in juvenile spondyloarthritis. Curr Rheumatol Rep 18:75
Magni-Manzoni S, Rossi F, Pistorio A et al (2003) Prognostic factors for radiographic progression, radiographic damage, and disability in juvenile idiopathic arthritis. Arthritis Rheum 48:3509–3517
Hudson JM, Karshafian R, Burns PN (2009) Quantification of flow using ultrasound and microbubbles: a disruption replenishment model based on physical principles. Ultrasound Med Biol 35:2007–2020
Muller L, Kellenberger CJ, Cannizzaro E et al (2009) Early diagnosis of temporomandibular joint involvement in juvenile idiopathic arthritis: a pilot study comparing clinical examination and ultrasound to magnetic resonance imaging. Rheumatology 48:680–685
Janow GL, Panghaal V, Trinh A et al (2011) Detection of active disease in juvenile idiopathic arthritis: sensitivity and specificity of the physical examination vs ultrasound. J Rheumatol 38:2671–2674
Murphy KJ, Rubin JM (1997) Power Doppler: it's a good thing. Semin Ultrasound CT MR 18:13–21
Krishnamurthy R, Yoo JH, Thapa M et al (2013) Water-bath method for sonographic evaluation of superficial structures of the extremities in children. Pediatr Radiol 43:S41–S47
Bertamino M, Rossi F, Pistorio A et al (2010) Development and initial validation of a radiographic scoring system for the hip in juvenile idiopathic arthritis. J Rheumatol 37:432–439
Bruyn GA, Naredo E, Iagnocco A et al (2015) The OMERACT ultrasound working group 10 years on: update at OMERACT 12. J Rheumatol 42:2172–2176
Wakefield RJ, Balint PV, Szkudlarek M et al (2005) Musculoskeletal ultrasound including definitions for ultrasonographic pathology. J Rheumatol 32:2485–2487
Tok F, Demirkaya E, Ozcakar L (2011) Musculoskeletal ultrasound in pediatric rheumatology. Pediatr Rheumatol Online J 9:25
Collado P, Naredo E, Calvo C et al (2007) Assessment of the joint recesses and tendon sheaths in healthy children by high-resolution B-mode and power Doppler sonography. Clin Exp Rheumatol 25:915–921
Panghaal V, Janow G, Trinh A et al (2012) Normal epiphyseal cartilage measurements in the knee in children: an alternative sonographic approach. J Ultrasound Med 31:49–53
Laurell L, Court-Payen M, Boesen M et al (2013) Imaging in juvenile idiopathic arthritis with a focus on ultrasonography. Clin Exp Rheumatol 31:135–148
Sheldon PJ, Forrester DM, Learch TJ (2005) Imaging of intraarticular masses. Radiographics 25:105–119
Valle M, Zamorani MP (2007) Bone and joint. In: Bianchi S, Martinoli C (eds) Ultrasound of the musculoskeletal system. Springer, Berlin, p 161
Alessi S, Depaoli R, Canepari M et al (2012) Baker's cyst in pediatric patients: ultrasonographic characteristics. J Ultrasound 15:76–81
Seil R, Rupp S, Jochum P et al (1999) Prevalence of popliteal cysts in children. A sonographic study and review of the literature. Arch Orthop Trauma Surg 119:73–75
Breton S, Jousse-Joulin S, Cangemi C et al (2011) Comparison of clinical and ultrasonographic evaluations for peripheral synovitis in juvenile idiopathic arthritis. Semin Arthritis Rheum 41:272–278
Sparchez M, Fodor D, Miu N (2010) The role of power Doppler ultrasonography in comparison with biological markers in the evaluation of disease activity in juvenile idiopathic arthritis. Med Ultrason 12:97–103
Shahin AA, Shaker OG, Kamal N et al (2002) Circulating interleukin-6, soluble interleukin-2 receptors, tumor necrosis factor alpha, and interleukin-10 levels in juvenile chronic arthritis: correlations with soft tissue vascularity assessed by power Doppler sonography. Rheumatol Int 22:84–88
Torp-Pedersen ST, Terslev L (2008) Settings and artefacts relevant in colour/power Doppler ultrasound in rheumatology. Ann Rheum Dis 67:143–149
Ranjan S, Jahan A, Yadav TP et al (2014) Evaluation of synovial inflammation in juvenile idiopathic arthritis by power color Doppler and spectral Doppler ultrasonography. Indian J Pediatr 81:29–35
Bhagwani DK, Jahan A, Yadav TP et al (2012) Diagnostic sensitivity and specificity of spectral color Doppler ultrasound indices in juvenile idiopathic arthritis. Ann Paediatr Rheum 1:163–170
Mandl P, Naredo E, Wakefield RJ et al (2011) A systematic literature review analysis of ultrasound joint count and scoring systems to assess synovitis in rheumatoid arthritis according to the OMERACT filter. J Rheumatol 38:2055–2062
Damasio MB, Malattia C, Martini A et al (2010) Synovial and inflammatory diseases in childhood: role of new imaging modalities in the assessment of patients with juvenile idiopathic arthritis. Pediatr Radiol 40:985–998
Ravelli A, Martini A (2003) Early predictors of outcome in juvenile idiopathic arthritis. Clin Exp Rheumatol 21:S89–S93
Malattia C, Damasio MB, Magnaguagno F et al (2008) Magnetic resonance imaging, ultrasonography, and conventional radiography in the assessment of bone erosions in juvenile idiopathic arthritis. Arthritis Rheum 59:1764–1772
Pradsgaard DO, Spannow AH, Heuck C et al (2013) Decreased cartilage thickness in juvenile idiopathic arthritis assessed by ultrasonography. J Rheumatol 40:1596–1603
Chan MW, Amirabadi A, Man C et al (2012) Techniques and challenges of 3D ultrasound and fusion 3DUS-MR imaging for assessment of knees in juvenile idiopathic arthritis. 98th scientific assembly and annual meeting of the Radiological Society of North America, Chicago, IL
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Conflicts of interest
The authors have no financial interests, investigational or off-label uses to disclose.
Rights and permissions
About this article
Cite this article
Chauvin, N.A., Doria, A.S. Ultrasound imaging of synovial inflammation in juvenile idiopathic arthritis. Pediatr Radiol 47, 1160–1170 (2017). https://doi.org/10.1007/s00247-017-3934-6
Received:
Revised:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00247-017-3934-6